Medina A, Bell P R, Briggs J D, Brown J J, Fine A, Lever A F, Morton J J, Paton A M, Robertson J I, Tree M, Waite M A, Weir R, Winchester J
Br Med J. 1972 Dec 23;4(5842):694-6. doi: 10.1136/bmj.4.5842.694.
Circulating levels of renin, angiotensin I, and angiotensin II were increased in six patients with chronic renal failure and hypertension uncontrolled by dialysis and hypotensive drugs. Lower and often normal levels were found in 10 patients whose blood pressure was controlled by dialysis treatment. For a variety of reasons all patients were subjected to bilateral nephrectomy. The logarithm of the decrease in plasma concentrations of renin and angiotensin II was significantly related to the fall of blood pressure after operation. Plasma renin concentration correlated significantly with blood angiotensin I concentration and with plasma angiotensin II in samples taken before and after nephrectomy. Renin, angiotensin I, and angiotensin II were measurable in samples of blood taken 48 hours or more after the operation.
六名慢性肾衰竭且高血压不受透析和降压药物控制的患者，其循环中的肾素、血管紧张素I和血管紧张素II水平升高。在10名血压通过透析治疗得到控制的患者中，发现这些水平较低且常为正常。由于各种原因，所有患者均接受了双侧肾切除术。肾素和血管紧张素II血浆浓度下降的对数与术后血压下降显著相关。在肾切除术前和术后采集的样本中，血浆肾素浓度与血血管紧张素I浓度以及血浆血管紧张素II显著相关。在术后48小时或更长时间采集的血样中可检测到肾素、血管紧张素I和血管紧张素II。
