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Ultraviolet-sensitive mutator mutU4 of Escherichia coli inviable with polA.大肠杆菌对紫外线敏感的诱变基因mutU4，与polA基因不相容（无法存活）。
J Bacteriol. 1973 Jan;113(1):161-6. doi: 10.1128/jb.113.1.161-166.1973.
2
Ultraviolet-sensitive mutator strain of Escherichia coli K-12.大肠杆菌K-12的紫外线敏感突变株。
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3
Genetic analysis of a temperature-resistant revertant of the conditional lethal Escherichia coli double mutant polA12 uvrE502.条件致死型大肠杆菌双突变体polA12 uvrE502的温度抗性回复突变体的遗传分析。
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Conditional lethality of recA and recB derivatives of a strain of Escherichia coli K-12 with a temperature-sensitive deoxyribonucleic acid polymerase I.大肠杆菌K-12菌株的recA和recB衍生物与温度敏感型脱氧核糖核酸聚合酶I的条件致死性
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Molecular cloning of the uvrD gene of Escherichia coli that controls ultraviolet sensitivity and spontaneous mutation frequency.控制紫外线敏感性和自发突变频率的大肠杆菌uvrD基因的分子克隆。
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本文引用的文献

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Mutants of Escherichia coli K-12 defective in DNA repair and in genetic recombination.大肠杆菌K-12中DNA修复和基因重组存在缺陷的突变体。
Genetics. 1966 Jun;53(6):1137-50. doi: 10.1093/genetics/53.6.1137.
2
Three loci in Escherichia coli K-12 that control the excision of pyrimidine dimers and certain other mutagen products from DNA.大肠杆菌K-12中控制从DNA切除嘧啶二聚体和某些其他诱变产物的三个基因座。
Genetics. 1966 Jun;53(6):1119-36. doi: 10.1093/genetics/53.6.1119.
3
DNA repair and genetic recombination: studies on mutants of Escherichia coli defective in these processes.DNA修复与基因重组：对在这些过程中存在缺陷的大肠杆菌突变体的研究。
Radiat Res. 1966:Suppl 6:156+.
4
In vitro excision-repair of ultraviolet-irradiated transforming DNA from Bacillus subtilis.枯草芽孢杆菌紫外线照射转化DNA的体外切除修复
Proc Natl Acad Sci U S A. 1971 Dec;68(12):2967-71. doi: 10.1073/pnas.68.12.2967.
5
Replication and repair of DNA in cells of Escherichia coli treated with toluene.用甲苯处理的大肠杆菌细胞中DNA的复制与修复
Proc Natl Acad Sci U S A. 1970 Oct;67(2):674-81. doi: 10.1073/pnas.67.2.674.
6
Monofunctional alkylating agent-induced inactivation, mutagenesis and DNA degradation in an Escherichia coli mutant deficient in DNA polymerase.单功能烷化剂在缺乏DNA聚合酶的大肠杆菌突变体中诱导的失活、诱变和DNA降解。
Mol Gen Genet. 1971;111(4):357-67. doi: 10.1007/BF00569788.
7
Ultraviolet- and X-ray-induced responses of a deoxyribonucleic acid polymerase-deficient mutant of Escherichia coli.紫外线和X射线诱导的大肠杆菌脱氧核糖核酸聚合酶缺陷型突变体的反应
J Bacteriol. 1971 Jul;107(1):61-7. doi: 10.1128/jb.107.1.61-67.1971.
8
Inviability of recA- derivatives of the DNA polymerase mutant of De Lucia and Cairns.德卢西亚和凯恩斯的DNA聚合酶突变体的recA-衍生物的非生存能力。
J Mol Biol. 1971 Jun 14;58(2):631-4. doi: 10.1016/0022-2836(71)90377-9.
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Repair of damage induced by ultraviolet light in DNA polymerase-defective Escherichia coli cells.DNA聚合酶缺陷型大肠杆菌细胞中紫外线诱导损伤的修复
J Mol Biol. 1971 Jun 14;58(2):623-30. doi: 10.1016/0022-2836(71)90376-7.
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Host cell reactivation in strains of E. coli lacking DNA polymerase activity in vitro.体外缺乏DNA聚合酶活性的大肠杆菌菌株中的宿主细胞复活。
Nat New Biol. 1971 Jan 20;229(3):82-4. doi: 10.1038/newbio229082a0.

大肠杆菌对紫外线敏感的诱变基因mutU4，与polA基因不相容（无法存活）。

Ultraviolet-sensitive mutator mutU4 of Escherichia coli inviable with polA.

作者信息

Siegel E C

出版信息

J Bacteriol. 1973 Jan;113(1):161-6. doi: 10.1128/jb.113.1.161-166.1973.

DOI:10.1128/jb.113.1.161-166.1973
PMID:4347245
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC251613/
Abstract

Attempts to transduce the ultraviolet-sensitive mutator lesion mutU4 into strains deficient in deoxyribonucleic acid polymerase I (polA) were unsuccessful. Mutator recombinants were found when the polA recipient had first been reverted to Pol(+) by selection for resistance to methyl methanesulfonate. The inviability of the mutU4 polA double mutant was demonstrated by a reduction in the absolute number of transductants when the recipient was polA as compared with Pol(+), and selection was made for markers very close to mutU4. Double mutants containing mutU4 and polA4, which determines a cold-sensitive polymerase, were unable to grow at 24 C, the nonpermissive temperature.

摘要

将对紫外线敏感的诱变损伤mutU4导入缺乏脱氧核糖核酸聚合酶I（polA）的菌株的尝试未成功。当通过选择对甲磺酸甲酯的抗性使polA受体首先回复为Pol（+）时，发现了诱变重组体。当受体为polA时，与Pol（+）相比，转导子的绝对数量减少，这证明了mutU4 polA双突变体的不可存活性，并对非常接近mutU4的标记进行了选择。含有mutU4和polA4（决定一种冷敏感聚合酶）的双突变体在非允许温度24℃下无法生长。