自身免疫性疾病中的循环免疫复合物与单核细胞Fc功能
Circulating immune complexes and monocyte Fc function in autoimmune diseases.
作者信息
Kávai M, Lukács K, Sonkoly I, Páloczi K, Szegedi G
出版信息
Ann Rheum Dis. 1979 Feb;38(1):79-83. doi: 10.1136/ard.38.1.79.
Abstract
The phagocytosis of separated and adherent monocytes of patients with systemic lupus erythematosus is subnormal as compared to controls on the basis of latex and yeast uptake. The monocytes from the same patients react with antibody-coated sheep red blood cells in a significantly higher degree than normal monocytes. There is a correlation between the percentage of reactive monocytes and the serum immune complex content. After brief treatment of patients with levamisole the phagocytic function of monocytes is restored and at the same time the circulating immune complex content is decreased.
摘要
与对照组相比，基于乳胶和酵母摄取情况，系统性红斑狼疮患者分离的黏附单核细胞的吞噬作用低于正常水平。同一患者的单核细胞与抗体包被的绵羊红细胞反应的程度明显高于正常单核细胞。反应性单核细胞的百分比与血清免疫复合物含量之间存在相关性。用左旋咪唑对患者进行简短治疗后，单核细胞的吞噬功能恢复，同时循环免疫复合物含量降低。
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