灵长类RNA肿瘤病毒样DNA由RNA依赖性DNA聚合酶在来自新鲜人类急性白血病血细胞的病毒样颗粒中内源性合成。
Primate RNA tumor virus-like DNA synthesized endogenously by RNA-dependent DNA polymerase in virus-like particles from fresh human acute leukemic blood cells.
作者信息
Gallo R C, Miller N R, Saxinger W C, Gillespie D
出版信息
Proc Natl Acad Sci U S A. 1973 Nov;70(11):3219-24. doi: 10.1073/pnas.70.11.3219.
Abstract
A particle of discrete biochemical composition was purified from fresh, unfrozen peripheral blood leukocytes of human patients with acute myeloblastic leukemia. This particle endogenously synthesized DNA by use of an RNA primer and template. About half of the DNA sequences synthesized in the presence of actinomycin D hybridized to RNA isolated from type-C sarcoma viruses of primates or mice; lower annealing values were obtained with RNA isolated from other sarcoma or leukemia viruses. The results confirm and extend previous results from molecular hybridization experiments related to the existence in human leukemia of components of RNA tumor viruses.
摘要
从患有急性髓细胞性白血病的人类患者的新鲜、未冷冻外周血白细胞中纯化出一种具有离散生化组成的颗粒。该颗粒利用RNA引物和模板内源性合成DNA。在放线菌素D存在的情况下合成的约一半DNA序列与从灵长类动物或小鼠的C型肉瘤病毒中分离出的RNA杂交；从其他肉瘤或白血病病毒中分离出的RNA获得的退火值较低。这些结果证实并扩展了先前与人类白血病中RNA肿瘤病毒成分的存在相关的分子杂交实验结果。
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