关于类固醇对小鼠病毒感染影响的进一步研究。
Further studies on the influence of steroids on viral infection in mice.
作者信息
Giron D J, Allen P T, Pindak F F, Schmidt J P
出版信息
Infect Immun. 1973 Aug;8(2):151-5. doi: 10.1128/iai.8.2.151-155.1973.
Certain steroids have been reported to enhance experimental viral infections, whereas others have little or no effect. Interference with the interferon system has been suggested as a possible mechanism for the viral infection-enhancing (VIE) activity of hormones. In the present study, steroids (prednisolone, progesterone, testosterone) which had no effect on MM virus infection demonstrated VIE activity against Mayaro virus infection. It is suggested that the VIE activity of a hormone may be dependent on the viral agent used for challenge. Data are also presented which suggest that, in addition to interference with the interferon system, the VIE activity of steroid hormones may be the result of at least two other actions: (i) alteration of cell membranes; (ii) stimulation of initial viral replication.
据报道，某些类固醇会增强实验性病毒感染，而其他类固醇则几乎没有影响或没有影响。干扰干扰素系统被认为是激素增强病毒感染（VIE）活性的一种可能机制。在本研究中，对MM病毒感染无影响的类固醇（泼尼松龙、孕酮、睾酮）对马亚罗病毒感染表现出VIE活性。有人提出，激素的VIE活性可能取决于用于攻击的病毒病原体。还提供了数据表明，除了干扰干扰素系统外，类固醇激素的VIE活性可能至少是其他两种作用的结果：（i）细胞膜的改变；（ii）刺激病毒的初始复制。
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