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巨细胞病毒:将非容许性细胞转化为对病毒复制具有容许性的状态。

Cytomegalovirus: conversion of nonpermissive cells to a permissive state for virus replication.

作者信息

St Jeor S, Rapp F

出版信息

Science. 1973 Sep 14;181(4104):1060-1. doi: 10.1126/science.181.4104.1060.

Abstract

Human embryonic kidney cells are epithelioid cells which are normally nonpermissive for in vitro replication of human cytomegalovirus. These cells were converted to a permissive state for the virus by prior treatment with 5-iodo-2'-deoxyuridine. When this method was used, a nonpermissive cell was made permissive to an infecting virus.

摘要

人胚肾细胞是上皮样细胞,通常对人巨细胞病毒的体外复制不敏感。通过先用5-碘-2'-脱氧尿苷处理,这些细胞被转化为对该病毒敏感的状态。当使用这种方法时,一个不敏感细胞变得对感染病毒敏感。

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