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PLC/PRF/5（亚历山大）肝癌细胞系：进一步的特性鉴定及感染性研究。

PLC/PRF/5 (Alexander) hepatoma cell line: further characterization and studies of infectivity.

作者信息

Daemer R J, Feinstone S M, Alexander J J, Tully J G, London W T, Wong D C, Purcell R H

出版信息

Infect Immun. 1980 Nov;30(2):607-11. doi: 10.1128/iai.30.2.607-611.1980.

DOI:10.1128/iai.30.2.607-611.1980
PMID:6160110
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC551353/
Abstract

The Alexander hepatoma cell line, PLC/PRF/5, was studied for evidence of hepatitis B virus markers and alpha-fetoprotein. Only hepatitis B surface antigen and alpha-fetoprotein were detected. Induction experiments with 5-iodo-2'-deoxyuridine and inoculation of chimpanzees with whole cells or tissue culture fluid did not reveal evidence of synthesis of additional hepatitis B virus markers or of production of infectious virus.

摘要

对亚历山大肝癌细胞系PLC/PRF/5进行了研究，以寻找乙肝病毒标志物和甲胎蛋白的证据。仅检测到乙肝表面抗原和甲胎蛋白。用5-碘-2'-脱氧尿苷进行诱导实验，以及用全细胞或组织培养液接种黑猩猩，均未发现合成其他乙肝病毒标志物或产生传染性病毒的证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f949/551353/a934763ccbc8/iai00179-0289-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f949/551353/e6bd87a24801/iai00179-0289-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f949/551353/3a25f3eaddef/iai00179-0289-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f949/551353/a934763ccbc8/iai00179-0289-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f949/551353/e6bd87a24801/iai00179-0289-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f949/551353/3a25f3eaddef/iai00179-0289-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f949/551353/a934763ccbc8/iai00179-0289-c.jpg

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本文引用的文献

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State of hepatitis B viral DNA in a human hepatoma cell line.人肝癌细胞系中乙肝病毒DNA的状态
J Virol. 1980 Feb;33(2):795-806. doi: 10.1128/JVI.33.2.795-806.1980.
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Immunofluorescence identification of Mycoplasma on agar by use of incident illumination.利用落射光在琼脂上对支原体进行免疫荧光鉴定。
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Human MiR-544a Modulates SELK Expression in Hepatocarcinoma Cell Lines.人源微小RNA-544a调节肝癌细胞系中SELK的表达。
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Novel mechanism of antibodies to hepatitis B virus in blocking viral particle release from cells.新型乙型肝炎病毒抗体阻断病毒粒子从细胞中释放的机制。
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Establishment and characterization of a new human hepatocellular carcinoma cell line.一种新的人肝癌细胞系的建立与鉴定
In Vitro. 1984 Jun;20(6):493-504. doi: 10.1007/BF02619623.
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A new human hepatocellular carcinoma cell line (KYN-1) with a transformation to adenocarcinoma.一种新的转化为腺癌的人肝癌细胞系（KYN-1）
In Vitro Cell Dev Biol. 1986 Nov;22(11):637-46. doi: 10.1007/BF02623477.
Science. 1971 Oct 8;174(4005):153-5. doi: 10.1126/science.174.4005.153.
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Australia antigen as a marker of propagation of the serum hepatitis virus in liver cultures.澳大利亚抗原作为血清型肝炎病毒在肝培养物中增殖的标志物。
Nature. 1972 Mar 10;236(5341):78-81. doi: 10.1038/236078a0.
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Localization of hepatitis B antigen in liver organ cultures.乙肝抗原在肝器官培养物中的定位
Br Med J. 1973 May 26;2(5864):482. doi: 10.1136/bmj.2.5864.482.
6
Hepatis B virus antigen development in cultured human hepatocytes.培养的人肝细胞中乙型肝炎病毒抗原的产生
Proc Soc Exp Biol Med. 1973 Dec;144(3):845-51. doi: 10.3181/00379727-144-37695.
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Cytomegalovirus: conversion of nonpermissive cells to a permissive state for virus replication.巨细胞病毒：将非容许性细胞转化为对病毒复制具有容许性的状态。
Science. 1973 Sep 14;181(4104):1060-1. doi: 10.1126/science.181.4104.1060.
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Cytomegalovirus replication in cells pretreated with 5-iodo-2'-deoxyuridine.巨细胞病毒在经5-碘-2'-脱氧尿苷预处理的细胞中的复制。
J Virol. 1973 Jun;11(6):986-90. doi: 10.1128/JVI.11.6.986-990.1973.
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