Benton W H, Ward R L
Appl Environ Microbiol. 1982 Apr;43(4):861-8. doi: 10.1128/aem.43.4.861-868.1982.
Cultures of 17 established cell lines were tested against 105 enteric virus types for capacity to support viral replication as indicated by cytopathogenic effect production. Enhancement of susceptibility by treatment of the cells with 5-iododeoxyuridine was evaluated in parallel with untreated cells. Cytopathogenic effect was produced in two or more cell lines by every virus tested except six strains of group A coxsackie virus. No cell line was found to be susceptible to these six virus types. In general, treatment with 5-iododeoxyuridine provided a more rapid onset of cytopathogenic effect in susceptible cells and in some instances resulted in refractory cells becoming permissive to viral replication. The use of 5-iododeoxyuridine allowed two human embryonic lines (HEL-299 and L-132), in combination, to be susceptible to all but the six group A coxsackie virus strains.
针对105种肠道病毒类型，检测了17种已建立的细胞系支持病毒复制的能力，病毒复制通过细胞病变效应的产生来表明。同时评估了用5-碘脱氧尿苷处理细胞对未处理细胞敏感性的增强作用。除了6株A组柯萨奇病毒外，每种测试病毒都在两种或更多种细胞系中产生了细胞病变效应。未发现有细胞系对这6种病毒类型敏感。一般来说，用5-碘脱氧尿苷处理能使敏感细胞更快出现细胞病变效应，在某些情况下还能使原本难治的细胞变得允许病毒复制。使用5-碘脱氧尿苷使两种人类胚胎细胞系（HEL-299和L-132）联合起来，除了6株A组柯萨奇病毒外，对所有病毒都敏感。
