猿猴病毒40与宿主细胞的相互作用。I. 由猿猴病毒40的ts*101温度敏感早期突变体转化的3T3小鼠细胞中猿猴病毒40大T抗原的温度敏感调节。
Simian virus 40-host cell interactions. I. Temperature-sensitive regulation of SV40 T antigen in 3T3 mouse cells transformed by the ts*101 temperature-sensitive early mutant of SV40.
作者信息
Robb J A
出版信息
J Virol. 1973 Nov;12(5):1187-90. doi: 10.1128/JVI.12.5.1187-1190.1973.
Abstract
BALB/3T3 and Swiss/3T3 mouse cells transformed at permissive temperature (33 C) by the early temperature-sensitive mutant of simian virus 40 (SV40), ts()101, exhibited a temperature-dependent modulation of SV40 tumor (T) antigen as assayed by immunofluorescence. The percentage of T antigen-positive nuclei in ts()101 transformed cells was reduced at restrictive temperature (39 C) when compared to 33 C and to wild-type SV40 transformed cells at either 33 C or 39 C. The percentage of T antigen-positive nuclei in ts()101 transformed cells returned to the 33 C control level when the cells were shifted from 39 to 33 C. The ts()101 transformed cells could be superinfected with wild-type, but not ts(*)101, virions at 39 C as assayed by an increase in T antigen-positive nuclei.
摘要
在允许温度（33℃）下被猴病毒40（SV40）的早期温度敏感突变体ts（）101转化的BALB/3T3和瑞士/3T3小鼠细胞，通过免疫荧光检测显示出SV40肿瘤（T）抗原的温度依赖性调节。与33℃时相比，以及与在33℃或39℃下的野生型SV40转化细胞相比，ts（）101转化细胞中T抗原阳性细胞核的百分比在限制温度（39℃）下降低。当细胞从39℃转移到33℃时，ts（）101转化细胞中T抗原阳性细胞核的百分比恢复到33℃时的对照水平。通过T抗原阳性细胞核数量的增加检测发现，ts（）101转化细胞在39℃时可被野生型病毒粒子超感染，但不能被ts（*）101病毒粒子超感染。
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