Keith A D, Snipes W
Science. 1974 Feb 15;183(4125):666-8. doi: 10.1126/science.183.4125.666.
The protoplasmic viscosity was studied by using a small spin label having high permeability and broad solubility properties and nickel chloride as an extracellular spin-subtracting agent to localize signal inside cells. The viscosity is variable and in some cells is many times that of water or phospholipids, suggesting that lateral diffusion in biological membranes is important to cell function.
通过使用一种具有高渗透性和广泛溶解性的小自旋标记物以及氯化镍作为细胞外自旋减法剂来定位细胞内信号,对原生质粘度进行了研究。粘度是可变的,在某些细胞中是水或磷脂的许多倍,这表明生物膜中的横向扩散对细胞功能很重要。