蓖麻毒素对体外蛋白质合成的抑制作用：60S核糖体亚基作为毒素的作用靶点。
Inhibition by ricin of protein synthesis in vitro: 60 S ribosomal subunit as the target of the toxin.
作者信息
Sperti S, Montanaro L, Mattioli A, Stirpe F
出版信息
Biochem J. 1973 Nov;136(3):813-5. doi: 10.1042/bj1360813.
Abstract
Poly(U)-directed polyphenylalanine synthesis by rat liver ribosomes is strongly inhibited by ricin. Experiments involving hybridization between subunits derived from normal and ricin-treated ribosomes demonstrate that the 60S subunit is the site of action of the toxin. The toxin inactivates the 60S subunit independently of the presence of the 40S subunit.
摘要
蓖麻毒素强烈抑制大鼠肝脏核糖体由多聚尿苷酸指导的聚苯丙氨酸合成。涉及来自正常核糖体和经蓖麻毒素处理的核糖体的亚基之间杂交的实验表明，60S亚基是毒素的作用位点。毒素使60S亚基失活，与40S亚基的存在无关。
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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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Ricin - a potent inhibitor of protein synthesis.蓖麻毒素——一种强大的蛋白质合成抑制剂。
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Interaction of polypeptide chain elongation factors with rat liver ribosomal subunits.多肽链延伸因子与大鼠肝脏核糖体亚基的相互作用。
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Dissociation of mammalian polyribosomes into subunits by puromycin.嘌呤霉素使哺乳动物多核糖体解离为亚基。
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The function of 80 S ribosomal subunits and effects of some antibiotics.80S核糖体亚基的功能及某些抗生素的作用。
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Ribosomes, G-factor and siomycin.核糖体、G因子和硫链丝菌素。
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The peptidyl transferase activity of ribosomes.核糖体的肽基转移酶活性。
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Inhibition by ricin of protein synthesis in vitro. Ribosomes as the target of the toxin.蓖麻毒素对体外蛋白质合成的抑制作用。核糖体作为毒素的作用靶点。
Biochem J. 1973 Nov;136(3):677-83. doi: 10.1042/bj1360677.
9
Treatment of abrin and ricin with -mercaptoethanol opposite effects on their toxicity in mice and their ability to inhibit protein synthesis in a cell-free system.用β-巯基乙醇处理相思子毒素和蓖麻毒素，对它们在小鼠体内的毒性以及在无细胞系统中抑制蛋白质合成的能力产生相反的影响。
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Thiostrepton: a ribosomal inhibitor of translocation.硫链丝菌素：一种核糖体转位抑制剂。
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