劳氏肉瘤病毒的脱氧核糖核酸聚合酶：双链脱氧核糖核酸合成机制的研究
Deoxyribonucleic acid polymerase of Rous sarcoma virus: studies on the mechanism of double-stranded deoxyribonucleic acid synthesis.
作者信息
Faras A, Fanshier L, Garapin A C, Levinson W, Bishop J M
出版信息
J Virol. 1971 May;7(5):539-48. doi: 10.1128/JVI.7.5.539-548.1971.
Abstract
The deoxyribonucleic acid (DNA) polymerase of Rous sarcoma virus synthesizes both single- and double-stranded DNA, utilizing the ribonucleic acid (RNA) of the viral genome as the initial template. Results of pulse-chase experiments indicate that the single-stranded DNA serves as unconserved template and precursor for the synthesis of double-stranded DNA. The latter reaction is apparently initiated in association with the viral RNA and may involve a partially double-stranded intermediate form.
摘要
劳氏肉瘤病毒的脱氧核糖核酸（DNA）聚合酶以病毒基因组的核糖核酸（RNA）为初始模板，合成单链和双链DNA。脉冲追踪实验结果表明，单链DNA作为双链DNA合成的非保守模板和前体。后一种反应显然是与病毒RNA相关联启动的，可能涉及一种部分双链的中间形式。
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