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1
Deoxyribonucleic acid polymerase of Rous sarcoma virus: studies on the mechanism of double-stranded deoxyribonucleic acid synthesis.劳氏肉瘤病毒的脱氧核糖核酸聚合酶：双链脱氧核糖核酸合成机制的研究
J Virol. 1971 May;7(5):539-48. doi: 10.1128/JVI.7.5.539-548.1971.
2
Deoxyribonucleic acid polymerases of Rous sarcoma virus: kinetics of deoxyribonucleic acid synthesis and specificity of the products.劳氏肉瘤病毒的脱氧核糖核酸聚合酶：脱氧核糖核酸合成动力学及产物特异性
J Virol. 1971 Feb;7(2):227-32. doi: 10.1128/JVI.7.2.227-232.1971.
3
Deoxyribonucleic acid polymerase of Rous sarcoma virus: reaction conditions and analysis of the reaction product nucleic acids.劳氏肉瘤病毒的脱氧核糖核酸聚合酶：反应条件及反应产物核酸的分析
J Virol. 1971 Nov;8(5):730-41. doi: 10.1128/JVI.8.5.730-741.1971.
4
Deoxyribonucleic acid polymerase associated with Rous sarcoma virus and avian myeloblastosis virus: properties of the enzyme and its product.与劳氏肉瘤病毒和禽成髓细胞瘤病毒相关的脱氧核糖核酸聚合酶：酶及其产物的特性
J Virol. 1970 Nov;6(5):589-98. doi: 10.1128/JVI.6.5.589-598.1970.
5
Ribonucleic acid directed deoxyribonucleic acid synthesis by the purified deoxyribonucleic acid polymerase of Rous sarcoma virus. Characterization of the enzymatic product.劳斯肉瘤病毒纯化的脱氧核糖核酸聚合酶催化的核糖核酸指导的脱氧核糖核酸合成。酶促产物的特性
Biochemistry. 1972 Jun 6;11(12):2343-51. doi: 10.1021/bi00762a021.
6
Deoxyribonucleic acid polymerase(s) of Rous sarcoma virus: effects of virion-associated endonuclease on the enzymatic product.劳氏肉瘤病毒的脱氧核糖核酸聚合酶：病毒体相关核酸内切酶对酶促产物的影响。
J Virol. 1971 Jul;8(1):17-27. doi: 10.1128/JVI.8.1.17-27.1971.
7
Purification and characterization of the deoxyribonucleic acid polymerase associated with Rous sarcoma virus.与劳氏肉瘤病毒相关的脱氧核糖核酸聚合酶的纯化与特性分析
Biochemistry. 1972 Jun 6;11(12):2334-42. doi: 10.1021/bi00762a020.
8
Ribonuclease-sensitive deoxyribonucleic acid polymerase activity in uninfected rat cells and rat cells infected with Rous sarcoma virus.未感染的大鼠细胞和感染劳氏肉瘤病毒的大鼠细胞中对核糖核酸酶敏感的脱氧核糖核酸聚合酶活性
J Virol. 1971 Nov;8(5):630-42. doi: 10.1128/JVI.8.5.630-642.1971.
9
Comparison of immature (rapid harvest) and mature Rous sarcoma virus particles.未成熟（快速收获）的劳斯肉瘤病毒颗粒与成熟劳斯肉瘤病毒颗粒的比较。
Virology. 1972 Dec;50(3):851-64. doi: 10.1016/0042-6822(72)90439-4.
10
DNA polymerase in defective Rous sarcoma virus.缺陷型劳氏肉瘤病毒中的DNA聚合酶。
Virology. 1971 May;44(2):457-62. doi: 10.1016/0042-6822(71)90278-9.

引用本文的文献

1
Two classes of cytoplasmic viral RNA synthesized early in productive infection with adenovirus 2.在腺病毒2的生产性感染早期合成的两类细胞质病毒RNA。
J Virol. 1974 Oct;14(4):751-7. doi: 10.1128/JVI.14.4.751-757.1974.
2
Isolation and characterization of a protein that stimulates DNA synthesis from avian myeloblastosis virus.从禽成髓细胞瘤病毒中分离并鉴定一种刺激DNA合成的蛋白质。
Proc Natl Acad Sci U S A. 1972 Aug;69(8):2331-5. doi: 10.1073/pnas.69.8.2331.
3
Virus-specific ribonucleic acid in cells producing rous sarcoma virus: detection and characterization.产生劳氏肉瘤病毒的细胞中的病毒特异性核糖核酸：检测与特性分析
J Virol. 1972 Jun;9(6):891-902. doi: 10.1128/JVI.9.6.891-902.1972.
4
RNA-dependent DNA polymerase activity of RNA tumor viruses. II. Directing influence of RNA in the reaction.RNA肿瘤病毒的RNA依赖性DNA聚合酶活性。II. 反应中RNA的直接导向作用。
J Virol. 1972 Jan;9(1):130-42. doi: 10.1128/JVI.9.1.130-142.1972.
5
Deoxyribonucleic acid polymerase of Rous sarcoma virus: reaction conditions and analysis of the reaction product nucleic acids.劳氏肉瘤病毒的脱氧核糖核酸聚合酶：反应条件及反应产物核酸的分析
J Virol. 1971 Nov;8(5):730-41. doi: 10.1128/JVI.8.5.730-741.1971.
6
In vitro transcription of the avian oncornavirus genome by the RNA-directed DNA polymerase: effect of actinomycin D on the extent of transcription.禽致癌病毒基因组的RNA指导DNA聚合酶体外转录：放线菌素D对转录程度的影响。
J Virol. 1977 Jul;23(1):209-12. doi: 10.1128/JVI.23.1.209-212.1977.
7
In vitro transcription of 70S RNA by the RNA-directed DNA polymerase of Rouse sarcoma virus: lack of influence of RNase H.劳氏肉瘤病毒的RNA指导DNA聚合酶对70S RNA的体外转录：核糖核酸酶H的影响缺失
J Virol. 1975 Jan;17(1):291-5. doi: 10.1128/JVI.17.1.291-295.1976.
8
In vitro transcription of DNA from the 70S RNA of Rous sarcoma virus: identification and characterization of various size classes of DNA transcripts.来自劳氏肉瘤病毒70S RNA的DNA体外转录：不同大小类别的DNA转录本的鉴定与表征
J Virol. 1975 Nov;16(5):1220-8. doi: 10.1128/JVI.16.5.1220-1228.1975.

本文引用的文献

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Forms of deoxyribonucleic acid produced by virions of the ribonucleic acid tumor viruses.由核糖核酸肿瘤病毒的病毒粒子产生的脱氧核糖核酸形式。
J Virol. 1971 Jan;7(1):106-11. doi: 10.1128/JVI.7.1.106-111.1971.
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Formation of viral RNA-DNA hybrid molecules by the DNA polymerase of sarcoma-leukaemia viruses.肉瘤白血病病毒的DNA聚合酶形成病毒RNA-DNA杂交分子。
Nature. 1970 Sep 5;227(5262):1026-8. doi: 10.1038/2271026a0.
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The biochemistry of RNA bacteriophage replication.RNA噬菌体复制的生物化学
Annu Rev Biochem. 1970;39:527-60. doi: 10.1146/annurev.bi.39.070170.002523.
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Deoxyribonucleic acid polymerases of Rous sarcoma virus: kinetics of deoxyribonucleic acid synthesis and specificity of the products.劳氏肉瘤病毒的脱氧核糖核酸聚合酶：脱氧核糖核酸合成动力学及产物特异性
J Virol. 1971 Feb;7(2):227-32. doi: 10.1128/JVI.7.2.227-232.1971.
5
Deoxyribonucleic acid polymerase associated with avian tumor viruses: secondary structure of the deoxyribonucleic acid product.与禽肿瘤病毒相关的脱氧核糖核酸聚合酶：脱氧核糖核酸产物的二级结构
J Virol. 1971 Jan;7(1):77-86. doi: 10.1128/JVI.7.1.77-86.1971.
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Mechanism of carcinogenesis by RNA tumor viruses. 3. Formation of RNA, DNA complex and duplex DNA molecules by the DNA polymerase (s) of avian myeloblastosis virus.RNA肿瘤病毒的致癌机制。3. 禽成髓细胞瘤病毒的DNA聚合酶形成RNA-DNA复合物和双链DNA分子。
Proc Natl Acad Sci U S A. 1970 Nov;67(3):1432-9. doi: 10.1073/pnas.67.3.1432.
7
Deoxyribonucleic acid polymerase associated with Rous sarcoma virus and avian myeloblastosis virus: properties of the enzyme and its product.与劳氏肉瘤病毒和禽成髓细胞瘤病毒相关的脱氧核糖核酸聚合酶：酶及其产物的特性
J Virol. 1970 Nov;6(5):589-98. doi: 10.1128/JVI.6.5.589-598.1970.
8
Complementarity between Rous sarcoma virus (RSV) RNA and the in vitro-synthesized DNA of the virus-associated DNA polymerase.劳氏肉瘤病毒（RSV）RNA与病毒相关DNA聚合酶的体外合成DNA之间的互补性。
Virology. 1970 Nov;42(3):783-8. doi: 10.1016/0042-6822(70)90325-9.
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DNA polymerases of Rous sarcoma virus: delineation of two reactions with actinomycin.劳氏肉瘤病毒的DNA聚合酶：放线菌素对两种反应的描述
Nature. 1970 Oct 31;228(5270):433-5. doi: 10.1038/228433a0.
10
Synthetic DNA-RNA hybrids and RNA-RNA duplexes as templates for the polymerases of the oncogenic RNA viruses.合成的DNA-RNA杂交体和RNA-RNA双链体作为致癌RNA病毒聚合酶的模板。
Nature. 1970 Oct 31;228(5270):430-2. doi: 10.1038/228430a0.

劳氏肉瘤病毒的脱氧核糖核酸聚合酶：双链脱氧核糖核酸合成机制的研究

Deoxyribonucleic acid polymerase of Rous sarcoma virus: studies on the mechanism of double-stranded deoxyribonucleic acid synthesis.

作者信息

Faras A, Fanshier L, Garapin A C, Levinson W, Bishop J M

出版信息

J Virol. 1971 May;7(5):539-48. doi: 10.1128/JVI.7.5.539-548.1971.

DOI:10.1128/JVI.7.5.539-548.1971
PMID:4326751
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC356161/
Abstract

The deoxyribonucleic acid (DNA) polymerase of Rous sarcoma virus synthesizes both single- and double-stranded DNA, utilizing the ribonucleic acid (RNA) of the viral genome as the initial template. Results of pulse-chase experiments indicate that the single-stranded DNA serves as unconserved template and precursor for the synthesis of double-stranded DNA. The latter reaction is apparently initiated in association with the viral RNA and may involve a partially double-stranded intermediate form.

摘要

劳氏肉瘤病毒的脱氧核糖核酸（DNA）聚合酶以病毒基因组的核糖核酸（RNA）为初始模板，合成单链和双链DNA。脉冲追踪实验结果表明，单链DNA作为双链DNA合成的非保守模板和前体。后一种反应显然是与病毒RNA相关联启动的，可能涉及一种部分双链的中间形式。