劳氏肉瘤病毒的脱氧核糖核酸聚合酶：脱氧核糖核酸合成动力学及产物特异性
Deoxyribonucleic acid polymerases of Rous sarcoma virus: kinetics of deoxyribonucleic acid synthesis and specificity of the products.
作者信息
Garapin A C, Fanshier L, Leong J A, Jackson J, Levinson W, Bishop J M
出版信息
J Virol. 1971 Feb;7(2):227-32. doi: 10.1128/JVI.7.2.227-232.1971.
Abstract
The deoxyribonucleic acid (DNA) polymerase(s) of Rous sarcoma virus synthesizes two principal products-single-stranded DNA in the form of a DNA:ribonucleic acid (RNA) hybrid and double-stranded DNA. All of the single-stranded product and 50% of the double-stranded product can be hybridized to 70S viral RNA. These results, in combination with data obtained by analysis of the kinetics of double-stranded DNA synthesis, indicate that the synthesis of double-stranded DNA is a sequel to the synthesis of single-stranded DNA and is dependent upon the latter for the provision of initial template.
摘要
劳氏肉瘤病毒的脱氧核糖核酸（DNA）聚合酶可合成两种主要产物：呈DNA:核糖核酸（RNA）杂交体形式的单链DNA和双链DNA。所有单链产物以及50%的双链产物都能与70S病毒RNA杂交。这些结果，再结合通过双链DNA合成动力学分析所获得的数据，表明双链DNA的合成是单链DNA合成的后续过程，并且依赖于单链DNA来提供初始模板。
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