Takada A, Imamura Y, Takada Y
Clin Exp Immunol. 1979 Feb;35(2):324-8.
The relationships between the haemolytic activities of complement and its components were studied. The activities studied included CH50 (classical pathway), AP50 (alternative pathway), CV50 (early part of alternative pathway) and C(3--9)H50 ((the late part of both pathways). The components included C3, C4, C5, C9, B and D. There was a good correlation between CH50 and AP50. AP50 had a good correlation with B and CV50. There was no correlation between AP50 and C(3--9)H50, and none between C(3--9)H50 and C5 or C9. AP50 may primarily represent changes in the early part of the alternative pathway. C(3--9)H50 is not influenced by respective changes in the amounts of C5 or C9. Since cell lesion is now considered to be caused by a unit of C5b to C9, a change in each component of C5 to C9 may not influence haemolytic activity.
对补体及其各成分的溶血活性之间的关系进行了研究。所研究的活性包括CH50（经典途径）、AP50（替代途径）、CV50（替代途径早期部分）和C(3--9)H50（两条途径的晚期部分）。所涉及的成分包括C3、C4、C5、C9、B和D。CH50与AP50之间存在良好的相关性。AP50与B和CV50具有良好的相关性。AP50与C(3--9)H50之间无相关性，C(3--9)H50与C5或C9之间也无相关性。AP50可能主要代表替代途径早期部分的变化。C(3--9)H50不受C5或C9各自量的变化影响。由于现在认为细胞损伤是由C5b至C9的一个单位引起的，C5至C9各成分的变化可能不会影响溶血活性。
