人类乳腺和结肠浸润性肿瘤中的酶活性。
Enzyme activity in invasive tumors of human breast and colon.
作者信息
Bosmann H B, Hall T C
出版信息
Proc Natl Acad Sci U S A. 1974 May;71(5):1833-7. doi: 10.1073/pnas.71.5.1833.
Abstract
Elevated levels of glycoprotein:sialyltransferase activity (EC 2.4.99.1; CMP-N-acetylneuraminate: D-galactosyl-glycoprotein N-acetylneuraminyltransferase) were found in human malignant neoplastic tissues compared to normal, benign, and "preneoplastic" tissues. This increase was not due to the cell density of the tissue. Elevated levels of certain proteases and glycosidases were also found. The increase in transferase activity may be associated with altered membrane synthesis in the neoplastic state; changes in the activity of degradative enzymes may be associated with tumor invasiveness and maintenance of the neoplastic state. Measurements on human tumors are possibly more directly relevant to cancer than those described for transformed fibroblastic cells in vitro.
摘要
与正常组织、良性组织和“肿瘤前”组织相比，在人类恶性肿瘤组织中发现糖蛋白：唾液酸转移酶活性（EC 2.4.99.1；CMP-N-乙酰神经氨酸：D-半乳糖基糖蛋白N-乙酰神经氨酸转移酶）水平升高。这种升高并非由于组织的细胞密度。还发现某些蛋白酶和糖苷酶水平升高。转移酶活性的增加可能与肿瘤状态下膜合成的改变有关；降解酶活性的变化可能与肿瘤侵袭性和肿瘤状态的维持有关。对人类肿瘤的测量可能比体外转化成纤维细胞所描述的测量与癌症更直接相关。
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