• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

3',5'-单磷酸腺苷对粒细胞黏附的影响

The effect of 3',5'-adenosine monophosphate on granulocyte adhesion.

作者信息

Bryant R E, Sutcliffe M C

出版信息

J Clin Invest. 1974 Nov;54(5):1241-4. doi: 10.1172/JCI107868.

DOI:10.1172/JCI107868
PMID:4370901
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC301672/
Abstract

Human granulocyte adhesion to glass capillary tubes was tested in the presence of agents that increase intracellular levels of cyclic 3',5'-adenosine monophosphate (cAMP). Adhesion was significantly reduced by 10(-3)-10(-4) M dibutyryl cAMP, 10(-4)-10(-6) M prostaglandin E(1) (PGE(1)), 10(-4)-10(-6) M histamine, or 10(-3) M theophylline. Adhesion was not suppressed by 10(-4) M theophylline unless it was combined with PGE(1) or histamine. Eosinophil and basophil adhesion was especially sensitive to suppression by the above agents. These findings suggest that intracellular cAMP may play a role in regulation of adhesiveness of human basophils, eosinophils, and neutrophils.

摘要

在能提高细胞内环磷酸腺苷（cAMP）水平的试剂存在的情况下，对人粒细胞与玻璃毛细管的黏附性进行了测试。10(-3)-10(-4)M的二丁酰cAMP、10(-4)-10(-6)M的前列腺素E(1)（PGE(1)）、10(-4)-10(-6)M的组胺或10(-3)M的茶碱可使黏附性显著降低。10(-4)M的茶碱不会抑制黏附，除非它与PGE(1)或组胺联合使用。嗜酸性粒细胞和嗜碱性粒细胞的黏附性对上述试剂的抑制特别敏感。这些发现表明，细胞内cAMP可能在调节人嗜碱性粒细胞、嗜酸性粒细胞和中性粒细胞的黏附性方面发挥作用。

相似文献

1
The effect of 3',5'-adenosine monophosphate on granulocyte adhesion.3',5'-单磷酸腺苷对粒细胞黏附的影响
J Clin Invest. 1974 Nov;54(5):1241-4. doi: 10.1172/JCI107868.
2
The depression of phagocytosis by exogenous cyclic nucleotides, prostaglandins, and theophylline.外源性环核苷酸、前列腺素及茶碱对吞噬作用的抑制
J Cell Biol. 1973 Nov;59(2 Pt 1):480-90. doi: 10.1083/jcb.59.2.480.
3
Hemolytic plaque formation by leukocytes in vitro. Control by vasoactive hormones.白细胞在体外形成溶血空斑。血管活性激素的调控
J Clin Invest. 1974 Jan;53(1):13-21. doi: 10.1172/JCI107530.
4
Regulation of Ig-induced eosinophil degranulation by adenosine 3',5'-cyclic monophosphate.3',5'-环磷酸腺苷对免疫球蛋白诱导的嗜酸性粒细胞脱颗粒的调节作用
J Immunol. 1991 Apr 15;146(8):2712-8.
5
The effects of cyclic AMP on leucocyte inhibitory factor (LIF) production and on the inhibition of leucocyte migration.环磷酸腺苷对白细胞抑制因子（LIF）产生及白细胞迁移抑制的影响。
Clin Exp Immunol. 1976 Apr;24(1):42-8.
6
Theophylline accelerates human granulocyte apoptosis not via phosphodiesterase inhibition.茶碱并非通过抑制磷酸二酯酶来加速人类粒细胞凋亡。
J Clin Invest. 1997 Oct 1;100(7):1677-84. doi: 10.1172/JCI119692.
7
Histamine release induced by human leukocyte lysates. Reabsorption of previously released histamine after exposure to cyclic amp-active agents.人白细胞裂解物诱导的组胺释放。暴露于环磷酸腺苷活性药物后先前释放组胺的重吸收。
J Clin Invest. 1973 Aug;52(8):1834-40. doi: 10.1172/JCI107365.
8
Cyclic 3',5'-adenosine monophosphate in the human lukocyte: synthesis, degradation, andeffects n neutrophil candidacidal activity.人白细胞中的环3',5'-腺苷单磷酸：合成、降解及其对中性粒细胞杀念珠菌活性的影响
J Clin Invest. 1971 Apr;50(4):920-9. doi: 10.1172/JCI106564.
9
Studies of effects of cyclic adenosine 3',5'-monophosphate in regulation of human hemopoiesis in vitro.3',5'-环磷酸腺苷在体外调节人类造血作用的研究。
In Vitro. 1973 Sep-Oct;9(2):86-91. doi: 10.1007/BF02616005.
10
Complement-mediated release of histamine from human basophils. II. Biochemical characterization of the reaction.补体介导的人嗜碱性粒细胞组胺释放。II. 反应的生化特性
J Immunol. 1976 Aug;117(2):450-6.

引用本文的文献

1
Hemocyte-hemocyte adhesion and nodulation reactions of the greater wax moth, Galleria mellonella are influenced by cholera toxin and its B-subunit.大蜡螟（Galleria mellonella）的血细胞-血细胞黏附及结瘤反应受霍乱毒素及其B亚基的影响。
Results Immunol. 2012 Feb 25;2:54-65. doi: 10.1016/j.rinim.2012.02.002. eCollection 2012.
2
Regulation of eosinophil adhesion by lysophosphatidylcholine via a non-store-operated Ca2+ channel.溶血磷脂酰胆碱通过非储存性钙离子通道对嗜酸性粒细胞黏附的调节作用。
Am J Respir Cell Mol Biol. 2007 May;36(5):585-93. doi: 10.1165/rcmb.2006-0391OC. Epub 2007 Jan 11.
3
Theophylline accelerates human granulocyte apoptosis not via phosphodiesterase inhibition.茶碱并非通过抑制磷酸二酯酶来加速人类粒细胞凋亡。
J Clin Invest. 1997 Oct 1;100(7):1677-84. doi: 10.1172/JCI119692.
4
Enhancement of granulocyte-endothelial cell adherence and granulocyte-induced cytotoxicity by platelet release products.血小板释放产物增强粒细胞与内皮细胞的黏附及粒细胞诱导的细胞毒性。
Proc Natl Acad Sci U S A. 1982 Nov;79(22):7019-23. doi: 10.1073/pnas.79.22.7019.
5
Thromboxane A2 mediates augmented polymorphonuclear leukocyte adhesiveness.血栓素A2介导多形核白细胞黏附性增强。
J Clin Invest. 1980 Sep;66(3):406-14. doi: 10.1172/JCI109870.
6
Inhibition by prostaglandins of leukotriene B4 release from activated neutrophils.前列腺素对活化中性粒细胞释放白三烯B4的抑制作用。
Proc Natl Acad Sci U S A. 1983 Jul;80(14):4349-53. doi: 10.1073/pnas.80.14.4349.
7
Comparative studies on the adhesiveness of granulocytes of guinea pig and man.豚鼠与人粒细胞黏附性的比较研究。
J Comp Physiol B. 1989;159(4):481-9. doi: 10.1007/BF00692420.
8
The neutrophil adherence assay as a method for detecting unique anti-inflammatory agents.中性粒细胞黏附试验作为一种检测独特抗炎剂的方法。
Agents Actions. 1978 Apr;8(3):258-62. doi: 10.1007/BF01966612.
9
Propranolol antagonizes the anti-inflammatory effect of alcohol and improves survival of infected intoxicated rabbits.普萘洛尔可拮抗酒精的抗炎作用，并提高感染中毒兔的存活率。
J Clin Invest. 1978 Sep;62(3):554-9. doi: 10.1172/JCI109160.
10
Motility and adhesiveness in human neutrophils. Effects of chemotactic factors.人类中性粒细胞的运动性和黏附性。趋化因子的作用。
J Clin Invest. 1979 Feb;63(2):221-9. doi: 10.1172/JCI109293.

本文引用的文献

1
Functional and metabolic properties of polymorphonuclear leucocytes. II. The influence of a lipopolysaccharide endotoxin.多形核白细胞的功能和代谢特性。II. 脂多糖内毒素的影响。
J Exp Med. 1960 May 1;111(5):689-704. doi: 10.1084/jem.111.5.689.
2
Functional and metabolic properties of polymorphonuclear leucocytes. I. Observations on the requirements and consequences of particle ingestion.多形核白细胞的功能和代谢特性。I. 关于颗粒摄取的需求和后果的观察。
J Exp Med. 1960 May 1;111(5):667-87. doi: 10.1084/jem.111.5.667.
3
Studies on the pathogenesis of acute inflammation. II. The action of cortisone on the inflammatory response to thermal injury.急性炎症发病机制的研究。II. 可的松对热损伤炎症反应的作用。
J Exp Med. 1955 Dec 1;102(6):669-76. doi: 10.1084/jem.102.6.669.
4
Studies on the cellular immunology of acute bacterial infections.急性细菌感染的细胞免疫学研究。
Harvey Lect. 1951;Series 47:72-98.
5
Improved method for direct counting of basophil leucocytes.嗜碱性白细胞直接计数的改良方法。
J Clin Pathol. 1966 Jul;19(4):402. doi: 10.1136/jcp.19.4.402.
6
A method for quantitation of human leukocyte adhesion to glass.
Proc Soc Exp Biol Med. 1972 Oct;141(1):196-202. doi: 10.3181/00379727-141-36741.
7
Studies on human leukocyte motility. II. Effects of bacterial endotoxin on leukocyte migration, adhesiveness, and aggregation.人类白细胞运动性研究。II. 细菌内毒素对白细胞迁移、黏附及聚集的影响。
Yale J Biol Med. 1967 Dec;40(3):192-204.
8
Studies on human leukocyte motility. I. Effects of alterations in pH, electrolyte concentration, and phagocytosis on leukocyte migration, adhesiveness, and aggregation.人类白细胞运动性研究。I. 酸碱度、电解质浓度及吞噬作用的改变对白细胞迁移、黏附及聚集的影响。
J Exp Med. 1966 Sep 1;124(3):483-99. doi: 10.1084/jem.124.3.483.
9
Effect of osmolalities comparable to those of the renal medulla on function of human polymorphonuclear leukocytes.与肾髓质渗透压相当的渗透压对人多形核白细胞功能的影响。
J Infect Dis. 1972 Jul;126(1):1-10. doi: 10.1093/infdis/126.1.1.
10
Mechanisms of lysosomal enzyme release from human leukocytes. II. Effects of cAMP and cGMP, autonomic agonists, and agents which affect microtubule function.人白细胞溶酶体酶释放的机制。II. 环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）、自主神经激动剂以及影响微管功能的药物的作用
J Clin Invest. 1974 Jan;53(1):297-309. doi: 10.1172/JCI107550.