3',5'-单磷酸腺苷对粒细胞黏附的影响
The effect of 3',5'-adenosine monophosphate on granulocyte adhesion.
作者信息
Bryant R E, Sutcliffe M C
出版信息
J Clin Invest. 1974 Nov;54(5):1241-4. doi: 10.1172/JCI107868.
Abstract
Human granulocyte adhesion to glass capillary tubes was tested in the presence of agents that increase intracellular levels of cyclic 3',5'-adenosine monophosphate (cAMP). Adhesion was significantly reduced by 10(-3)-10(-4) M dibutyryl cAMP, 10(-4)-10(-6) M prostaglandin E(1) (PGE(1)), 10(-4)-10(-6) M histamine, or 10(-3) M theophylline. Adhesion was not suppressed by 10(-4) M theophylline unless it was combined with PGE(1) or histamine. Eosinophil and basophil adhesion was especially sensitive to suppression by the above agents. These findings suggest that intracellular cAMP may play a role in regulation of adhesiveness of human basophils, eosinophils, and neutrophils.
摘要
在能提高细胞内环磷酸腺苷（cAMP）水平的试剂存在的情况下，对人粒细胞与玻璃毛细管的黏附性进行了测试。10(-3)-10(-4)M的二丁酰cAMP、10(-4)-10(-6)M的前列腺素E(1)（PGE(1)）、10(-4)-10(-6)M的组胺或10(-3)M的茶碱可使黏附性显著降低。10(-4)M的茶碱不会抑制黏附，除非它与PGE(1)或组胺联合使用。嗜酸性粒细胞和嗜碱性粒细胞的黏附性对上述试剂的抑制特别敏感。这些发现表明，细胞内cAMP可能在调节人嗜碱性粒细胞、嗜酸性粒细胞和中性粒细胞的黏附性方面发挥作用。
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