• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Effects of lysosomotropic agents on insulin interactions with adipocytes. Evidence for a lysosomal pathway for insulin processing and degradation.

作者信息

Marshall S, Olefsky J M

出版信息

J Biol Chem. 1979 Oct 25;254(20):10153-60.

PMID:489589
Abstract
摘要

相似文献

1
Effects of lysosomotropic agents on insulin interactions with adipocytes. Evidence for a lysosomal pathway for insulin processing and degradation.溶酶体促渗剂对胰岛素与脂肪细胞相互作用的影响。胰岛素加工和降解的溶酶体途径的证据。
J Biol Chem. 1979 Oct 25;254(20):10153-60.
2
Interactions between insulin and its receptors after the initial binding event. Functional heterogeneity and relationships to insulin degradation.初始结合事件后胰岛素与其受体之间的相互作用。功能异质性及其与胰岛素降解的关系。
Diabetes. 1979 May;28(5):460-71. doi: 10.2337/diab.28.5.460.
3
Internalized insulin-receptor complexes are unidirectionally translocated to chloroquine-sensitive degradative sites. Dependence on metabolic energy.内化的胰岛素受体复合物单向转运至对氯喹敏感的降解位点。对代谢能量的依赖性。
J Biol Chem. 1988 Apr 25;263(12):5961-9.
4
Separate intracellular pathways for insulin receptor recycling and insulin degradation in isolated rat adipocytes.分离的大鼠脂肪细胞中胰岛素受体再循环和胰岛素降解的细胞内独立途径。
J Cell Physiol. 1983 Nov;117(2):195-203. doi: 10.1002/jcp.1041170210.
5
Internalization and intracellular processing of insulin and insulin receptors in adipocytes.脂肪细胞中胰岛素及胰岛素受体的内化与细胞内加工过程
Metabolism. 1982 Jul;31(7):670-90. doi: 10.1016/0026-0495(82)90197-4.
6
Receptor mediated insulin degradation decreased by chloroquine in isolated rat adipocytes.在分离的大鼠脂肪细胞中，氯喹降低了受体介导的胰岛素降解。
J Biochem. 1980 Jul;88(1):39-44.
7
Characterization of insulin-induced receptor loss and evidence for internalization of the insulin receptor.胰岛素诱导的受体丢失的特征及胰岛素受体内化的证据。
Diabetes. 1981 Sep;30(9):746-53. doi: 10.2337/diab.30.9.746.
8
Evidence for recycling of insulin receptors in isolated rat adipocytes.大鼠分离脂肪细胞中胰岛素受体再循环的证据。
J Biol Chem. 1981 Nov 25;256(22):11464-70.
9
Diversity in the effects of extracellular ATP and adenosine on the cellular processing and physiologic actions of insulin in rat adipocytes.细胞外ATP和腺苷对大鼠脂肪细胞中胰岛素的细胞加工和生理作用影响的多样性。
J Biol Chem. 1987 Nov 5;262(31):15026-32.
10
The endocytotic-internalization pathway of insulin metabolism: relationship to insulin degradation and activation of glucose transport.胰岛素代谢的内吞内化途径：与胰岛素降解及葡萄糖转运激活的关系
Endocrinology. 1980 Dec;107(6):1937-45. doi: 10.1210/endo-107-6-1937.

引用本文的文献

1
Sphingosine kinase 2 regulates insulin receptor trafficking in hepatocytes.鞘氨醇激酶 2 调节肝细胞中胰岛素受体的运输。
Exp Biol Med (Maywood). 2023 Jan;248(1):44-51. doi: 10.1177/15353702221131886. Epub 2022 Nov 20.
2
Loss of insulin-induced inhibition of glucagon gene transcription in hamster pancreatic islet alpha cells by long-term insulin exposure.长期胰岛素暴露导致仓鼠胰岛α细胞中胰岛素诱导的胰高血糖素基因转录抑制作用丧失。
Diabetologia. 2008 Nov;51(11):2012-21. doi: 10.1007/s00125-008-1134-5. Epub 2008 Sep 2.
3
Robert Feulgen Prize Lecture 1993. The journey of the insulin receptor into the cell: from cellular biology to pathophysiology.
1993年罗伯特·福尔根奖讲座。胰岛素受体进入细胞的历程：从细胞生物学到病理生理学。
Histochemistry. 1993 Sep;100(3):169-84. doi: 10.1007/BF00269090.
4
Infectious entry pathway of influenza virus in a canine kidney cell line.流感病毒在犬肾细胞系中的感染性进入途径。
J Cell Biol. 1981 Dec;91(3 Pt 1):601-13. doi: 10.1083/jcb.91.3.601.
5
Glucose tolerance and respiratory activities of human liver biopsies: their interdependence.人肝脏活检组织的葡萄糖耐量与呼吸活动：它们之间的相互依存关系。
Dig Dis Sci. 1981 Dec;26(12):1104-8. doi: 10.1007/BF01295976.
6
Receptor-mediated insulin degradation and insulin-stimulated glycogenesis in cultured foetal hepatocytes.培养的胎儿肝细胞中受体介导的胰岛素降解及胰岛素刺激的糖原生成
Biochem J. 1982 Feb 15;202(2):333-41. doi: 10.1042/bj2020333.
7
Affinity change of the adipocyte receptor fails to alter insulin-stimulated glucose transport.脂肪细胞受体的亲和力变化未能改变胰岛素刺激的葡萄糖转运。
Biochem J. 1982 Jan 15;202(1):263-5. doi: 10.1042/bj2020263.
8
Evidence for insulin-induced internalization and degradation of insulin receptors in rat adipocytes.胰岛素诱导大鼠脂肪细胞中胰岛素受体内化和降解的证据。
Proc Natl Acad Sci U S A. 1982 Jan;79(2):427-31. doi: 10.1073/pnas.79.2.427.
9
Effects of insulin incubation on insulin binding, glucose transport, and insulin degradation by isolated rat adipocytes. Evidence for hormone-induced desensitization at the receptor and postreceptor level.胰岛素孵育对分离的大鼠脂肪细胞胰岛素结合、葡萄糖转运及胰岛素降解的影响。激素诱导受体及受体后水平脱敏的证据。
J Clin Invest. 1980 Oct;66(4):763-72. doi: 10.1172/JCI109914.
10
Internalization of polypeptide hormones: mechanism, intracellular localization and significance.多肽激素的内化：机制、细胞内定位及意义
Diabetologia. 1980 Apr;18(4):263-74. doi: 10.1007/BF00251003.