猿猴病毒40转化的3T3成纤维细胞培养物中的巨噬细胞移动抑制因子样活性。
MIF-like activity in simian virus 40-transformed 3T3 fibroblast cultures.
作者信息
Hammond M E, Roblin R O, Dvorak A M, Selvaggio S S, Black P H, Dvorak H F
出版信息
Science. 1974 Sep 13;185(4155):955-7. doi: 10.1126/science.185.4155.955.
PMID:4377757
Abstract
Simian virus 40-transformed fibroblasts (SV3T3), as compared with their untransformed counterparts (3T3), elaborate a macromolecular product that inhibits macrophage migration and causes macrophages to aggregate and lose one type of cell coat material. I'he SV3T3 cells also lack this surface material relative to 3T3 cells. There may be a relationz between migration inhibition factor (MIF), the cell coat, and cell migration.
摘要
与未转化的对应细胞（3T3）相比，猿猴病毒40转化的成纤维细胞（SV3T3）会产生一种大分子产物，该产物可抑制巨噬细胞迁移，并导致巨噬细胞聚集并失去一种细胞被物质。相对于3T3细胞，SV3T3细胞也缺乏这种表面物质。迁移抑制因子（MIF）、细胞被与细胞迁移之间可能存在关联。
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