Deal E C, McFadden E R, Ingram R H, Jaeger J J
J Appl Physiol Respir Environ Exerc Physiol. 1979 Mar;46(3):484-90. doi: 10.1152/jappl.1979.46.3.484.
We measured the temperature in the rectum and two esophageal sites (retrocardiac and retrotracheal) during exercise in eight asthmatic and six normal subjects while they breathed air at subfreezing, ambient, and body conditions. Various aspects of pulmonary mechanics were recorded before and after exercise. The asthmatic subjects developed the greatest airway obstruction following exercise with cold air and no response at body conditions. There were no changes in pulmonary mechanics in the postexercise period in the normal individuals with any of the inspired air conditions. Despite these divergent mechanical responses retrotracheal temperatures fell by the same magnitude below core values in both groups of subjects, indicating that identical degrees of airway cooling occurred. We conclude that rather than having a defect in the ability to condition inspired air, asthmatic subjects are more responsive to the effects of incompletely conditioned air.
我们在八名哮喘患者和六名正常受试者运动期间，测量了他们在吸入低于冰点、环境温度和体温的空气时直肠及两个食管部位（心后和气管后）的温度。在运动前后记录了肺力学的各个方面。哮喘患者在吸入冷空气运动后气道阻塞最为严重，而在体温条件下无反应。在任何吸入空气条件下，正常个体运动后肺力学均无变化。尽管有这些不同的力学反应，但两组受试者气管后温度均比核心温度下降相同幅度，表明气道冷却程度相同。我们得出结论，哮喘患者并非在调节吸入空气的能力上存在缺陷，而是对未完全调节的空气的影响更敏感。
