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2
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4
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J Clin Invest. 1974 Feb;53(2):591-9. doi: 10.1172/JCI107594.

本文引用的文献

1
Metabolism of l-ascorbic acid, dehydro-l'ascorbic acid, and diketo-l-gulonic acid in the guinea pig.豚鼠体内L-抗坏血酸、脱氢-L-抗坏血酸和二酮-L-古洛糖酸的代谢
J Biol Chem. 1952 Apr;195(2):599-606.
2
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
3
ENZYMATIC BASIS OF THE RESPIRATORY STIMULATION DURING PHAGOCYTOSIS.吞噬作用期间呼吸刺激的酶学基础。
Nature. 1964 Oct 17;204:255-7. doi: 10.1038/204255a0.
4
Improved method for the determination of blood glutathione.测定血液中谷胱甘肽的改进方法。
J Lab Clin Med. 1963 May;61:882-8.
5
Metabolic patterns in three types of phagocytizing cells.三种吞噬细胞中的代谢模式。
J Cell Biol. 1963 Jun;17(3):487-501. doi: 10.1083/jcb.17.3.487.
6
The biochemical basis of phagocytosis. IV. Some aspects of carbohydrate metabolism during phagocytosis.吞噬作用的生化基础。IV. 吞噬作用期间碳水化合物代谢的某些方面。
Biochemistry. 1962 Jan;1:159-66. doi: 10.1021/bi00907a024.
7
Functional and metabolic properties of polymorphonuclear leucocytes. II. The influence of a lipopolysaccharide endotoxin.多形核白细胞的功能和代谢特性。II. 脂多糖内毒素的影响。
J Exp Med. 1960 May 1;111(5):689-704. doi: 10.1084/jem.111.5.689.
8
Functional and metabolic properties of polymorphonuclear leucocytes. I. Observations on the requirements and consequences of particle ingestion.多形核白细胞的功能和代谢特性。I. 关于颗粒摄取的需求和后果的观察。
J Exp Med. 1960 May 1;111(5):667-87. doi: 10.1084/jem.111.5.667.
9
The biochemical basis of phagocytosis. I. Metabolic changes during the ingestion of particles by polymorphonuclear leukocytes.吞噬作用的生化基础。I. 多形核白细胞吞噬颗粒过程中的代谢变化。
J Biol Chem. 1959 Jun;234(6):1355-62.
10
The purification and properties of glutathione peroxidase of erythrocytes.红细胞谷胱甘肽过氧化物酶的纯化及其性质
J Biol Chem. 1959 Mar;234(3):502-6.

人类和豚鼠白细胞中的呼吸作用与葡萄糖氧化：比较研究

Respiration and glucose oxidation in human and guinea pig leukocytes: comparative studies.

作者信息

Baehner R L, Gilman N, Karnovsky M L

出版信息

J Clin Invest. 1970 Apr;49(4):692-700. doi: 10.1172/JCI106281.

DOI:10.1172/JCI106281
PMID:4392648
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC322524/
Abstract

A comparison has been made of the metabolic shifts in human and guinea pig leukocytes when they phagocytize. Respiration of guinea pig polymorphonuclear leukocytes (PMN) and the increment during phagocytosis were each about 2(1/2)-fold that of human PMN. This was also true of the direct oxidation of glucose-6-P (hexose monophosphate shunt). Enzymes potentially responsible for these phenomena have been compared in each species. Cyanide-insensitive NADH oxidase and NADPH oxidase were measured and only the formed exhibited adequate activity to account for the respiratory stimulus durintg phagocytosis. The hydrogen peroxide formed by this enzyme stimulates the hexose monophosphate shunt by oxidizing glutathione which upon reduction by an NADPH-linked glutathione reductase provides NADP to drive the hexose monophosphate shunt. Other linkages between respiratory stimulation and that of the hexose monophosphate shunt also pertain in the guinea pig.

摘要

对人类和豚鼠白细胞吞噬时的代谢变化进行了比较。豚鼠多形核白细胞（PMN）的呼吸作用以及吞噬过程中的增加量分别约为人类PMN的2.5倍。葡萄糖-6-P的直接氧化（磷酸己糖旁路）也是如此。对每个物种中可能导致这些现象的酶进行了比较。测量了对氰化物不敏感的NADH氧化酶和NADPH氧化酶，只有后者表现出足够的活性来解释吞噬过程中的呼吸刺激。该酶产生的过氧化氢通过氧化谷胱甘肽来刺激磷酸己糖旁路，而谷胱甘肽在由与NADPH相关的谷胱甘肽还原酶还原后提供NADP以驱动磷酸己糖旁路。呼吸刺激与磷酸己糖旁路之间的其他联系在豚鼠中也存在。