Leckband E, Boyse E A
Science. 1971 Jun 18;172(3989):1258-60. doi: 10.1126/science.172.3989.1258.
Suspensions prepared from thymuses of TL(+) mice contain a majority of TL(+) cells and a minority of TL(-) cells. The graft versus host reactivity of the TL(-) population is much greater than that of the whole population, as judged by the numbers of cells required to give splenic enlargements in Simonsen's assay. It is proposed that the TL(-) thymocyte represents a stage in the differentiation of TL(+) thymocytes into immunocompetent lymphocytes.
从TL(+)小鼠胸腺制备的悬浮液中含有大多数TL(+)细胞和少数TL(-)细胞。根据在西蒙森试验中引起脾脏肿大所需的细胞数量判断，TL(-)群体的移植物抗宿主反应性比整个群体的要大得多。有人提出，TL(-)胸腺细胞代表了TL(+)胸腺细胞分化为免疫活性淋巴细胞的一个阶段。
