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Cis-platinum(II) diamine dichloride causes mutation, transformation, and sister-chromatid exchanges in cultured mammalian cells.

作者信息

Turnbull D, Popescu N C, DiPaolo J A, Myhr B C

出版信息

Mutat Res. 1979 Mar;66(3):267-75. doi: 10.1016/0165-1218(79)90088-0.

DOI:10.1016/0165-1218(79)90088-0
PMID:440327
Abstract

The anti-tumor agent cis-platinum(II) diamine dichloride caused dose-dependent toxicity in V79 Chinese hamster cells and in secondary Syrian hamster embryo cells. Chromosome aberrations were induced and positive dose--response relationships were observed for induction of sister-chromatid exchanges and 6-thioguanine-resistant mutations in V79 cells and morphologic transformation of secondary Syrian hamster embryo cells. The findings suggest that this chemical is a potential human carcinogen.

摘要

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引用本文的文献

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Environ Health Perspect. 1981 Aug;40:143-61. doi: 10.1289/ehp.8140143.
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