香烟烟雾冷凝物中小鼠皮肤致癌物的分级分离
Fractionation of mouse skin carcinogens in cagarette smoke condensate.
作者信息
Lee P N, Rothwell K, Whitehead J K
出版信息
Br J Cancer. 1977 Jun;35(6):730-42. doi: 10.1038/bjc.1977.114.
The results of a series of mouse-skin paintings are given for fractions prepared by two schemes designed to concentrate the polycyclic aromatic hydrocarbons (PAH) and their heterocyclic analogues (HETC) present in cigarette smoke condensate into single fractions. It is demonstrated that, for each group, a single index of tumour response, the "Weibull risk parameter" (WRP), can be calculated which, considered in conjunction with two other parameters common to all the groups, adequately describes the pattern of tumour incidence in that group. These indices can be used to calculate for each fraction a further statistic, the "tumorigenic ratio" (TR), which conveniently measures the activity of the fraction relative to whole-smoke condensate on a weight-for-weight basis. From the analyses it is shown that the separation processes can successfully concentrate all types of mouse-skin carcinogenic material, irrespective of the type of condensate used, and that a combination of processes prepares an active concentrate representing 2% by weight of the original condensate.
给出了一系列小鼠皮肤涂抹实验的结果，这些结果涉及通过两种方案制备的馏分，这两种方案旨在将香烟烟雾冷凝物中存在的多环芳烃（PAH）及其杂环类似物（HETC）浓缩到单一馏分中。结果表明，对于每组而言，可以计算出一个单一的肿瘤反应指标，即“威布尔风险参数”（WRP），该参数与所有组共有的另外两个参数相结合，能够充分描述该组中的肿瘤发生率模式。这些指标可用于为每个馏分计算另一个统计量，即“致瘤率”（TR），它可以方便地衡量该馏分相对于全烟雾冷凝物在重量对重量基础上的活性。分析表明，分离过程能够成功浓缩所有类型的小鼠皮肤致癌物质，无论使用何种类型的冷凝物，并且多种过程的组合制备出了一种活性浓缩物，其重量占原始冷凝物的2%。
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