Whitwam J G, Taylor A R, White J M
Anaesthesia. 1979 Feb;34(2):181-2. doi: 10.1111/j.1365-2044.1979.tb06275.x.
The administration of methylene blue to assist the identification of insulin secreting pancreatic adenomata, during surgery in a patient with normal haemoglobin and red cells, was associated with an increase in the methaemoglobin concentration from 0.6% to 7.1%. In patients with unstable haemoglobins or abnormalities of the hexose monophosphate pathway the administration of large amounts of methylene blue is potentially dangerous.
在一名血红蛋白和红细胞正常的患者手术过程中，给予亚甲蓝以协助识别分泌胰岛素的胰腺腺瘤，结果导致高铁血红蛋白浓度从0.6%升至7.1%。对于血红蛋白不稳定或磷酸己糖途径异常的患者，给予大量亚甲蓝具有潜在危险性。
