Arnadottir T, Reunanen M, Meurman O, Salmi A, Panelius M, Halonen P
Arch Neurol. 1979 May;36(5):261-5. doi: 10.1001/archneur.1979.00500410039004.
A longitudinal study on rubella, measles, and respiratory syncytial virus antibodies in serial serum and CSF specimens from 20 multiple sclerosis (MS) patients was performed, using solid-phase radioimmunoassay. Albumin and immunoglobulin G (IgG) levels were also measured to check the integrity of the blood-brain barrier and the intrathecal IgG production. All the patients had local IgG production in their CNA. A local antibody production against one or more of the viruses studied was evident in 15 patients. Fluctuations in the intrathecal viral antibody synthesis were evident in eight patients. No correlation was found between these changes and the clinical course of the disease. The results suggest that the intrathecal antibody synthesis in MS is only partially against any given virus, and in most patients the bulk of the oligoclonal CSF antibodies is against antigens other than those studied here.
采用固相放射免疫分析法，对20例多发性硬化症（MS）患者的系列血清和脑脊液标本中的风疹、麻疹和呼吸道合胞病毒抗体进行了纵向研究。还测量了白蛋白和免疫球蛋白G（IgG）水平，以检查血脑屏障的完整性和鞘内IgG的产生情况。所有患者的脑脊液中均有局部IgG产生。15例患者出现针对一种或多种所研究病毒的局部抗体产生。8例患者鞘内病毒抗体合成有波动。未发现这些变化与疾病临床进程之间存在相关性。结果表明，MS患者的鞘内抗体合成仅部分针对任何特定病毒，在大多数患者中，大部分寡克隆脑脊液抗体针对的是此处研究抗原以外的其他抗原。
