相移对大鼠被动回避反应的影响及氯氮卓的调节作用。
The effect of phase-shift on the passive avoidance response in rats and the modifying action of chlordiazepoxide.
作者信息
Davies J A, Navaratnam V, Redfern P H
出版信息
Br J Pharmacol. 1974 Jul;51(3):447-51. doi: 10.1111/j.1476-5381.1974.tb10681.x.
Abstract
1 In rats trained to a 12 h light-12 h dark cycle, advancing the phase by 6 h produced a resynchronization of the 24 h variation in passive avoidance response (PAR) which was completed after 10 days.2 The attainment of the new steady state was preceded by a period of disruption which was greatest 5 days after phase-shift.3 The presence of chlordiazepoxide (62.5-500 mug/ml) in the drinking water during the days after phase-shift produced a dose-dependent lessening of the disruptive effect of phase-shift, and a more rapid adaptation to the new light-dark cycle.
摘要
在训练为12小时光照-12小时黑暗周期的大鼠中，将相位提前6小时会使被动回避反应（PAR）的24小时变化重新同步，这在10天后完成。
在达到新的稳态之前有一段紊乱期，在相位转换后5天最为严重。
在相位转换后的几天里，饮用水中存在氯氮卓（62.5 - 500微克/毫升）会产生剂量依赖性地减轻相位转换的破坏作用，并更快地适应新的明暗周期。
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