藏茴香籽水提取物的拟胆碱作用。

Cholinomimetic effects of aqueous extracts from Carum copticum seeds.

作者信息

Devasankaraiah G, Hanin I, Haranath P S, Ramanamurthy P S

出版信息

Br J Pharmacol. 1974 Dec;52(4):613-4. doi: 10.1111/j.1476-5381.1974.tb09732.x.

DOI:10.1111/j.1476-5381.1974.tb09732.x

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1776902/

Abstract

An aqueous extract from roasted seeds of Carum copticum (omum) has cholinomimetic effects. It shows muscarinic effects on rabbit duodenum, guinea-pig ileum and rat jejunum, and on the blood pressure of rat and cat. These effects are blocked by atropine. It also has a nicotinic action on the frog rectus preparation and atropinized cat blood pressure. Its effect is potentiated by physostigmine and antagonized by cholinesterase or alkalinization. Paper and gas chromatography have confirmed the presence of acetylcholine and choline in the roasted omum seed extract.

摘要

藏茴香（孜然芹）烘焙种子的水提取物具有拟胆碱作用。它对兔十二指肠、豚鼠回肠和大鼠空肠以及大鼠和猫的血压显示出毒蕈碱样作用。这些作用可被阿托品阻断。它对青蛙腹直肌标本和阿托品化的猫血压也有烟碱样作用。毒扁豆碱可增强其作用，胆碱酯酶或碱化作用则可拮抗其作用。纸色谱法和气相色谱法已证实烘焙孜然芹种子提取物中存在乙酰胆碱和胆碱。

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本文引用的文献

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