淋巴细胞集落形成随年龄增长而减少。
Reduced lymphocyte colony formation with age.
作者信息
Alder S J, Morley A A, Seshadri R S
出版信息
Clin Exp Immunol. 1982 Jul;49(1):129-34.
The lymphocyte colony forming ability of 83 normal healthy individuals aged 17-89 was studied. The total lymphocyte count did not alter with age, but there was a decline in the colony forming ability of cells from people with increasing age (r = -0.68, P less than 0.001). This age related defect was further investigated in 11 mixing experiments using paired young and old individuals. It was found that the defect in aged individuals was due primarily to a defect in the number and/or proliferative ability of the colony forming cell.
对83名年龄在17 - 89岁的正常健康个体的淋巴细胞集落形成能力进行了研究。淋巴细胞总数不随年龄变化，但随着年龄增长，细胞的集落形成能力下降（r = -0.68，P小于0.001）。在11项使用配对的年轻和老年个体的混合实验中，对这种与年龄相关的缺陷进行了进一步研究。发现老年个体的缺陷主要归因于集落形成细胞数量和/或增殖能力的缺陷。
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