罗瓦洛尔——一种治疗胆固醇性胆结石的可能疗法。
Rowachol--a possible treatment for cholesterol gallstones.
作者信息
Doran J, Keighley M R, Bell G D
出版信息
Gut. 1979 Apr;20(4):312-7. doi: 10.1136/gut.20.4.312.
Abstract
It has been claimed that Rowachol, a proprietary choleretic, is occasionally successful in the treatment of gallstones. In gallstone patients we have examined its effect on the lipid composition of (1) samples of fasting gall bladder bile obtained at the time of cholecystectomy, and (2) T-tube bile on the tenth post-operative day. In a dose of two capsules, three times a day for only 48 hours, Rowachol significantly lowered the cholesterol solubility of both gall bladder (P less than 0.001) and T-tube bile (P less than 0.05). Rowachol in a dose of one capsule three times a day for 48 hours did not alter bile composition, while four capsules four times a day for a similar period caused a significant (P less than 0.05) deterioration in biliary lipid composition. The possible mechanisms of action of Rowachol and their therapeutic implications are discussed.
摘要
据称，一种专利利胆药罗瓦绍尔（Rowachol）偶尔对胆结石的治疗有效。在胆结石患者中，我们研究了它对以下两种胆汁脂质成分的影响：（1）胆囊切除术时获取的空腹胆囊胆汁样本；（2）术后第十天的T管胆汁。罗瓦绍尔仅服用48小时，剂量为每日三次，每次两粒胶囊，可显著降低胆囊胆汁（P<0.001）和T管胆汁（P<0.05）的胆固醇溶解度。罗瓦绍尔剂量为每日三次，每次一粒胶囊，服用48小时，不会改变胆汁成分，而在相同时间段内每日四次，每次四粒胶囊，则会导致胆汁脂质成分显著恶化（P<0.05）。本文讨论了罗瓦绍尔可能的作用机制及其治疗意义。
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