产前辐射与儿童癌症：因果关系还是巧合？
Antenatal irradiation and childhood cancer: causation or coincidence?
作者信息
Mole R H
出版信息
Br J Cancer. 1974 Sep;30(3):199-208. doi: 10.1038/bjc.1974.182.
Abstract
A re-analysis of published data from the Oxford Childhood Cancer Survey shows that the frequency of leukaemia and of solid cancers in childhood is greater following antenatal x-radiography, not only in singleton births but also in monozygotic and dizygotic twins. The radiography rate was 10% in singletons and 55% in twins. A similar excess of leukaemia and of solid cancers in the x-rayed with such different rates of radiography is strong evidence for irradiation as the cause. The low observed frequency of malignant disease in Japanese bomb survivors exposed in utero may not be in serious conflict with this conclusion, as has been supposed.
摘要
对牛津儿童癌症调查已发表数据的重新分析表明，产前接受X射线照射后，儿童白血病和实体癌的发病率会增加，这不仅在单胎分娩中如此，在单卵双胞胎和双卵双胞胎中也是如此。单胎的X射线照射率为10%，双胞胎为55%。在接受X射线照射且照射率差异如此之大的情况下，白血病和实体癌出现类似的超额发病率，这有力地证明了照射是病因。子宫内受到照射的日本原子弹幸存者中观察到的恶性疾病低发病率，可能并不像人们认为的那样与这一结论存在严重冲突。
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