Koulu M, Lammintausta R
J Clin Endocrinol Metab. 1979 Jul;49(1):70-2. doi: 10.1210/jcem-49-1-70.
The effect of subacute melatonin (250 mg every 8 h over a period of 40 h) and placebo treatment on L-tryptophan- and apomorphine-stimulated GH secretion was tested in 13 volunteers. Melatonin premedication significantly reduced the GH response to peroral L-tryptophan loading, suggesting that melatonin affects GH secretion in man by interfering with serotonergic transmission. In the apomorphine test, no significant difference in GH response was observed after melatonin when compared to placebo treatment. This suggests that dopaminergic mechanisms do not have a central role in mediating actions of melatonin on the hypothalamic-pituitary axis. It is further proposed that melatonin influences GH secretion at a suprahypophyseal level.
在13名志愿者中测试了亚急性褪黑素（40小时内每8小时250毫克）和安慰剂治疗对L-色氨酸和阿扑吗啡刺激的生长激素（GH）分泌的影响。褪黑素预处理显著降低了口服L-色氨酸负荷后GH的反应，这表明褪黑素通过干扰血清素能传递影响人体的GH分泌。在阿扑吗啡试验中，与安慰剂治疗相比，褪黑素后GH反应没有显著差异。这表明多巴胺能机制在介导褪黑素对下丘脑-垂体轴的作用中没有核心作用。进一步提出褪黑素在垂体上水平影响GH分泌。
