阿扑吗啡对正常受试者褪黑素分泌的影响。

Effect of apomorphine on melatonin secretion in normal subjects.

作者信息

Lal S, Isaac I, Pilapil C, Nair N P, Hariharasubramanian N, Guyda H, Quirion R

出版信息

Prog Neuropsychopharmacol Biol Psychiatry. 1987;11(2-3):229-33. doi: 10.1016/0278-5846(87)90065-0.

Abstract

There is some evidence in animals that dopamine (DA) affects melatonin secretion. The effect of apomorphine (Apo), a selective DA receptor agonist, and placebo on day-time melatonin secretion was studied in six normal men. Apo HCl in a dose (0.5 mg sc) which increased growth hormone secretion in all subjects had no effect on day-time melatonin concentrations in plasma. In keeping with other clinical studies these data suggest that melatonin secretion is not regulated by a DA mechanism in man.

摘要

在动物中有一些证据表明多巴胺（DA）会影响褪黑素的分泌。在六名正常男性中研究了阿扑吗啡（Apo）（一种选择性DA受体激动剂）和安慰剂对日间褪黑素分泌的影响。能使所有受试者生长激素分泌增加的剂量（0.5mg皮下注射）的盐酸阿扑吗啡对血浆中日间褪黑素浓度没有影响。与其他临床研究一致，这些数据表明在人类中褪黑素的分泌不受DA机制的调节。