Gelboin H V, Wiebel F, Diamond L
Science. 1970 Oct 9;170(3954):169-71. doi: 10.1126/science.170.3954.169.
Mouse skin contains aryl hydrocarbon hydroxylase which is highly inducible. The enzyme system is inhibited when 7,8-benzoflavone is added to homogenates of skin epidermis. 7,8-Benzoflavone also inhibits mouse skin tumorigenesis caused by repeated treatment with 9,10-dimethylbenzanthracene or by a single treatment with this chemical followed by weekly treatment with croton oil. These findings suggest that this enzyme system may be responsible for the activation of 9,10-dimethylbenzanthracene to its carcinogenic form.
小鼠皮肤含有高度可诱导的芳烃羟化酶。当将7,8-苯并黄酮添加到皮肤表皮匀浆中时，该酶系统会受到抑制。7,8-苯并黄酮还可抑制因反复用9,10-二甲基苯并蒽处理或用该化学物质单次处理后每周用巴豆油处理而导致的小鼠皮肤肿瘤发生。这些发现表明，该酶系统可能负责将9,10-二甲基苯并蒽激活为其致癌形式。
