培养的小鼠成纤维细胞中的生长控制：一种纯化生长因子诱导的多型性和促有丝分裂反应。
Growth control in cultured mouse fibroblasts: induction of the pleiotypic and mitogenic responses by a purified growth factor.
作者信息
Rudland P S, Seifert W, Gospodarowicz D
出版信息
Proc Natl Acad Sci U S A. 1974 Jul;71(7):2600-4. doi: 10.1073/pnas.71.7.2600.
Abstract
Addition of serum to quiescent mouse fibroblasts induces a series of macromolecular changes (a pleiotypic response) followed by DNA synthesis and cell division. A new pituitary hormone, fibroblast growth factor, and hydrocortisone acting at physiological concentrations can completely replace exogenously added serum for the induction of these events in lines of BALB/c 3T3 cells. The induction of cell growth is specific for cultured fibroblasts; no stimulation is observed for mouse epithelial cells or virally transformed fibroblasts.
摘要
向静止的小鼠成纤维细胞中添加血清会引发一系列大分子变化（一种多效性反应），随后是DNA合成和细胞分裂。一种新的垂体激素、成纤维细胞生长因子以及生理浓度的氢化可的松，能够完全替代外源添加的血清，从而在BALB/c 3T3细胞系中诱导这些事件。细胞生长的诱导对于培养的成纤维细胞具有特异性；在小鼠上皮细胞或病毒转化的成纤维细胞中未观察到刺激作用。
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