急性白血病初诊时及缓解期的血清铁蛋白
Serum ferritin in acute leukaemia at presentation and during remission.
作者信息
Parry D H, Worwood M, Jacobs A
出版信息
Br Med J. 1975 Feb 1;1(5952):245-7. doi: 10.1136/bmj.1.5952.245.
Abstract
In patients with acute myeloblastic leukaemia the mean serum ferritin concentration showed a twenty-five-fold increase compared with normal people, and in children with acute lymphoblastic leukaemia (A.L.L.) there was a thirteen-fold increase. The high concentration of circulating ferritin seemed to be related to increased synthesis by leukaemic cells. The return of serum concentrations to normal in A.L.L. patients after successful chemotherapy suggested that ferritin concentration may be a useful index of active disease and may help in prognosis.
摘要
急性髓细胞白血病患者的血清铁蛋白平均浓度比正常人高25倍，急性淋巴细胞白血病（A.L.L.）患儿的血清铁蛋白平均浓度则高13倍。循环铁蛋白浓度升高似乎与白血病细胞合成增加有关。A.L.L.患者化疗成功后血清浓度恢复正常，这表明铁蛋白浓度可能是疾病活动的一个有用指标，有助于预后判断。
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