Duvaldestin P, Mazze R I, Hazebrouck J, Nivoche Y, Cohen S E, Desmonts J M
Anesthesiology. 1979 Jul;51(1):41-6. doi: 10.1097/00000542-197907000-00009.
Serum bromide levels were measured in 115 anesthetists by use of x-ray fluorescence spectrometry. Bromide levels peaked at 184 +/- 21 micron in anesthetists regularly exposed to halothane (n = 20), at 58 +/- 4 micron in anesthetists sporadically exposed to halothane (n = 71), and at 46 +/- 3 micron in nonexposed anesthetists (n = 24). Kinetic studies were carried out in five other anesthetists after ten days of exposure to halothane. Average daily halothane concentration was 19.2 +/- 3.2 ppm; duration of exposure was 3.8 +/- 0.2 hours/day. Mean serum bromide level increased from 40 +/- 4 micron before exposure to 220 +/- 36 micron on the last day of exposure. Serum bromide half-life was 14 +/- 1.7 days. The study demonstrates that anesthetists debrominate halothane in a dose-related fashion. Serum bromide levels achieved, however, were far below those reported to result in clinical bromism.
通过X射线荧光光谱法对115名麻醉师的血清溴水平进行了测量。经常接触氟烷的麻醉师（n = 20）的溴水平峰值为184±21微克，偶尔接触氟烷的麻醉师（n = 71）为58±4微克，未接触氟烷的麻醉师（n = 24）为46±3微克。在另外五名麻醉师接触氟烷十天后进行了动力学研究。平均每日氟烷浓度为19.2±3.2 ppm；接触时间为3.8±0.2小时/天。血清溴水平从接触前的40±4微克增加到接触最后一天的220±36微克。血清溴半衰期为14±1.7天。该研究表明，麻醉师以剂量相关的方式使氟烷脱溴。然而，所达到的血清溴水平远低于据报道会导致临床溴中毒的水平。
