体外免疫反应。VI. 19S抗体合成中体内-体外差异的遗传控制。
Immune responses in vitro. VI. Genetic control of the in vivo-in vitro discrepancies in 19S antibody synthesis.
作者信息
Click R E, Benck L, Alter B J, Lovchik J C
出版信息
J Exp Med. 1972 Nov 1;136(5):1241-57. doi: 10.1084/jem.136.5.1241.
Abstract
The finding that the relationship of the in vitro and in vivo responses of different strains of mice is under genetic control indicates that at least two mechanisms must operate under in vivo conditions to control 19S antibody synthesis. One is involved in the termination of 19S antibody synthesis; the other has a regulatory role on the magnitude of the response. In light of these findings, various concepts based on other genetically controlled immune responses and on the limiting dilution technique should be reassessed. Furthermore, the suppressive in vivo mechanism may be an important type of control in the resistance or susceptibility to the establishment or maintainance of neoplasms.
摘要
不同品系小鼠的体外和体内反应关系受遗传控制这一发现表明，在体内条件下至少有两种机制参与控制19S抗体的合成。一种机制参与19S抗体合成的终止；另一种机制对反应强度起调节作用。鉴于这些发现，基于其他遗传控制的免疫反应和有限稀释技术的各种概念应重新评估。此外，体内抑制机制可能是肿瘤发生或维持的抗性或易感性控制的一种重要类型。
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