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有髓神经中的传导速度。I. 对细胞外钠离子和温度的实验依赖性

Propagation speed in myelinated nerve. I. Experimental dependence on external Na and on temperature.

作者信息

Hardy W L

出版信息

Biophys J. 1973 Oct;13(10):1054-70. doi: 10.1016/S0006-3495(73)86045-X.

DOI:10.1016/S0006-3495(73)86045-X
PMID:4542940
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1484345/
Abstract

Conduction speed (theta) in single myelinated Rana pipiens sciatic nerve fibers has been precisely measured using intracellular recording and on-line digital computer techniques. The dependence of relative speed on external Na concentration at 15 degrees C has been found to be ln(theta(1)/theta(2)) = 0.524 (+/-0.018) ln (Na(+)/Na(+)) + 0.003. Thus theta has very close to a square root dependence on Na(+) for these fibers. This experimental finding is not in complete agreement with a theoretical prediction based on a solution of the Hodgkin-Huxley (H.H.) equations. The effect of small temperature variations around 15 degrees C on theta has also been measured for Rana fibers in Ringer's solution. theta has close to an exponential dependence on T and a Q(10) of 2.95 has been estimated.

摘要

利用细胞内记录和在线数字计算机技术，精确测量了单个有髓的牛蛙坐骨神经纤维的传导速度（θ）。已发现，在15℃时，相对速度对外部钠离子浓度的依赖性为ln(θ(1)/θ(2)) = 0.524（±0.018）ln (Na⁺/Na⁺) + 0.003。因此，对于这些纤维，θ对Na⁺的依赖性非常接近平方根关系。这一实验发现与基于霍奇金-赫胥黎（H.H.）方程解的理论预测并不完全一致。对于林格氏液中的牛蛙纤维，还测量了15℃左右的小温度变化对θ的影响。θ对温度T接近指数依赖性，估计Q(10)为2.95。

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本文引用的文献

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Direct membrane resting and action potentials from single myelinated nerve fibers.来自单根有髓神经纤维的直接膜静息电位和动作电位。
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