有髓神经中的传导速度。I. 对细胞外钠离子和温度的实验依赖性
Propagation speed in myelinated nerve. I. Experimental dependence on external Na and on temperature.
作者信息
Hardy W L
出版信息
Biophys J. 1973 Oct;13(10):1054-70. doi: 10.1016/S0006-3495(73)86045-X.
Abstract
Conduction speed (theta) in single myelinated Rana pipiens sciatic nerve fibers has been precisely measured using intracellular recording and on-line digital computer techniques. The dependence of relative speed on external Na concentration at 15 degrees C has been found to be ln(theta(1)/theta(2)) = 0.524 (+/-0.018) ln (Na(+)/Na(+)) + 0.003. Thus theta has very close to a square root dependence on Na(+) for these fibers. This experimental finding is not in complete agreement with a theoretical prediction based on a solution of the Hodgkin-Huxley (H.H.) equations. The effect of small temperature variations around 15 degrees C on theta has also been measured for Rana fibers in Ringer's solution. theta has close to an exponential dependence on T and a Q(10) of 2.95 has been estimated.
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