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有髓神经中的传播速度。II. 对细胞外钠离子和温度的理论依赖性。

Propagation speed in myelinated nerve. II. Theoretical dependence on external Na and on temperature.

作者信息

Hardy W L

出版信息

Biophys J. 1973 Oct;13(10):1071-89. doi: 10.1016/S0006-3495(73)86046-1.

DOI:10.1016/S0006-3495(73)86046-1
PMID:4542941
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1484343/
Abstract

The Hodgkin-Huxley (H.H.) equations modified by Dodge for Rana pipiens myelinated nerve have been solved to determine how well the theory predicts the effects of changes of temperature and Na(+) on propagation. Conduction speed theta was found to have an approximately exponential dependence on temperature as was found experimentally, but the theoretical temperature coefficient (Q(10)) was low; 1.5 compared with the experimental finding of 2.95. theta was found to be a linear function of log (Na(+)) in contrast to the experimental finding of a square root dependence on Na(+). theta is 50% greater at one-fourth normal Na(+) than the theory predicts. The difference between the theoretical theta(Na(+)) and the experimental theta(Na(+)) is probably due to an imprecisely known variation of parameters and not to a fundamental inadequacy of the theory.

摘要

由道奇（Dodge）针对牛蛙有髓神经修改后的霍奇金 - 赫胥黎（H.H.）方程已被求解，以确定该理论在预测温度和细胞外钠离子浓度（Na⁺）变化对神经冲动传导影响方面的准确性。结果发现，传导速度θ与温度呈现近似指数关系，这与实验结果一致，但理论温度系数（Q₁₀）较低，为1.5，而实验测得的温度系数为2.95。与实验发现的θ与Na⁺的平方根关系不同，理论上θ是log(Na⁺)的线性函数。在细胞外钠离子浓度为正常浓度四分之一时，θ比理论预测值大50%。理论预测的θ(Na⁺)与实验测得的θ(Na⁺)之间的差异，可能是由于参数变化的不确定性导致，而非该理论本身存在根本性缺陷。

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本文引用的文献

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The permeability of the sodium channel to organic cations in myelinated nerve.有髓神经中钠通道对有机阳离子的通透性。
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Biophys J. 1973 Oct;13(10):1054-70. doi: 10.1016/S0006-3495(73)86045-X.