有髓神经中的传播速度。II. 对细胞外钠离子和温度的理论依赖性。
Propagation speed in myelinated nerve. II. Theoretical dependence on external Na and on temperature.
作者信息
Hardy W L
出版信息
Biophys J. 1973 Oct;13(10):1071-89. doi: 10.1016/S0006-3495(73)86046-1.
Abstract
The Hodgkin-Huxley (H.H.) equations modified by Dodge for Rana pipiens myelinated nerve have been solved to determine how well the theory predicts the effects of changes of temperature and Na(+) on propagation. Conduction speed theta was found to have an approximately exponential dependence on temperature as was found experimentally, but the theoretical temperature coefficient (Q(10)) was low; 1.5 compared with the experimental finding of 2.95. theta was found to be a linear function of log (Na(+)) in contrast to the experimental finding of a square root dependence on Na(+). theta is 50% greater at one-fourth normal Na(+) than the theory predicts. The difference between the theoretical theta(Na(+)) and the experimental theta(Na(+)) is probably due to an imprecisely known variation of parameters and not to a fundamental inadequacy of the theory.
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