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肿瘤结合免疫球蛋白。包被肿瘤细胞表面免疫球蛋白的体外消失及释放成分的一些特性。

Tumour-bound immunoglobulins. The in vitro disappearance of immunoglobulin from the surface of coated tumour cells, and some properties of released components.

作者信息

Ran M, Fish F, Witz I P, Klein G

出版信息

Clin Exp Immunol. 1974 Mar;16(3):335-53.

PMID:4549686
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1553942/
Abstract

Immunoglobulin-coated ascites tumour cells lose some of their immunoglobulin coat following their transfer to culture conditions. The uncoating process is metabolism-dependent and related to the turning over of cell-surface components. Uncoated tumour cells bind globulin isolated from tumour eluates more efficiently than coated cells. Analysis of the spent medium of short-term tumour cell cultures revealed the presence of both immunoglobulin and antigenic cell surface components.

摘要

免疫球蛋白包被的腹水肿瘤细胞在转移至培养条件后会失去部分免疫球蛋白包被。脱包被过程依赖于代谢，且与细胞表面成分的更新有关。未包被的肿瘤细胞比包被的细胞更有效地结合从肿瘤洗脱液中分离出的球蛋白。对短期肿瘤细胞培养的用过的培养基进行分析发现存在免疫球蛋白和抗原性细胞表面成分。

相似文献

1
Tumour-bound immunoglobulins. The in vitro disappearance of immunoglobulin from the surface of coated tumour cells, and some properties of released components.肿瘤结合免疫球蛋白。包被肿瘤细胞表面免疫球蛋白的体外消失及释放成分的一些特性。
Clin Exp Immunol. 1974 Mar;16(3):335-53.
2
Tumour-bound immunoglobulins. The in vitro fixation of radioiodine-labelled anti-immunoglobulin reagents by tumour cells.肿瘤结合免疫球蛋白。肿瘤细胞对放射性碘标记的抗免疫球蛋白试剂的体外固定作用。
Clin Exp Immunol. 1974 Mar;16(3):321-33.
3
Tumour-bound immunoglobulins. The fate of immunoglobulin disappearing from the surface of coated tumour cells.肿瘤结合免疫球蛋白。从包被肿瘤细胞表面消失的免疫球蛋白的命运。
Clin Exp Immunol. 1974 Mar;16(3):355-65.
4
Tumor-bound immunoglobulins: their possible role in circumventing antitumor immunity.肿瘤结合免疫球蛋白：它们在规避抗肿瘤免疫中的可能作用。
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Effect of cell density on the disappearance of cell surface immunoglobulins.细胞密度对细胞表面免疫球蛋白消失的影响。
Ann Immunol (Paris). 1978 Jan;129(1):89-96.
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Endocytosis by lymphocytes of complexes of anti-Ig with membrane-bound Ig.淋巴细胞对膜结合型免疫球蛋白与抗免疫球蛋白复合物的内吞作用。
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Cellular events folowing binding of antigen to lymphocytes.抗原与淋巴细胞结合后的细胞事件。
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Immunotherapy of a murine B cell tumor with antibodies and F(ab')2 fragments against idiotypic determinants of its cell surface IgM.用针对小鼠B细胞肿瘤细胞表面IgM独特型决定簇的抗体和F(ab')2片段对该肿瘤进行免疫治疗。
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Surface markers of small lymphocytes appearing in the mouse Ehrlich ascites tumour, host spleen and blood.小鼠艾氏腹水瘤、宿主脾脏和血液中出现的小淋巴细胞表面标志物。
Immunology. 1978 Mar;34(3):487-99.

引用本文的文献

1
Tumour-bound immunoglobulins. The fate of immunoglobulin disappearing from the surface of coated tumour cells.肿瘤结合免疫球蛋白。从包被肿瘤细胞表面消失的免疫球蛋白的命运。
Clin Exp Immunol. 1974 Mar;16(3):355-65.
2
Tumour-bound immunoglobulins. The in vitro fixation of radioiodine-labelled anti-immunoglobulin reagents by tumour cells.肿瘤结合免疫球蛋白。肿瘤细胞对放射性碘标记的抗免疫球蛋白试剂的体外固定作用。
Clin Exp Immunol. 1974 Mar;16(3):321-33.

本文引用的文献

1
Histocompatibility changes in tumors.肿瘤中的组织相容性变化。
J Cell Physiol Suppl. 1958 Dec;52(Supp 1):125-60; discussion 160-8. doi: 10.1002/jcp.1030520409.
2
The exchange of phospholipids between cultured chick embryo fibroblasts and their growth medium.培养的鸡胚成纤维细胞与其生长培养基之间磷脂的交换。
Exp Cell Res. 1969 Dec;58(2):365-78. doi: 10.1016/0014-4827(69)90517-5.
3
Suggestive evidence that the "blocking antibodies" of tumor-bearing individuals may be antigen--antibody complexes.有提示性证据表明，荷瘤个体的“封闭抗体”可能是抗原-抗体复合物。
Proc Natl Acad Sci U S A. 1971 Jun;68(6):1372-5. doi: 10.1073/pnas.68.6.1372.
4
Spontaneous release of cytotoxic alloantibody from viable cells sensitized in excess antibody.在过量抗体中致敏的活细胞自发释放细胞毒性同种抗体。
Immunology. 1971 Nov;21(5):829-38.
5
Tumour-bound immunoglobulins. The fate of immunoglobulin disappearing from the surface of coated tumour cells.肿瘤结合免疫球蛋白。从包被肿瘤细胞表面消失的免疫球蛋白的命运。
Clin Exp Immunol. 1974 Mar;16(3):355-65.
6
Tumour-bound immunoglobulins. The in vitro fixation of radioiodine-labelled anti-immunoglobulin reagents by tumour cells.肿瘤结合免疫球蛋白。肿瘤细胞对放射性碘标记的抗免疫球蛋白试剂的体外固定作用。
Clin Exp Immunol. 1974 Mar;16(3):321-33.
7
Blocking of lymphocyte-mediated cytotoxicity for rat hepatoma cells by tumour-specific antigen-antibody complexes.肿瘤特异性抗原-抗体复合物对大鼠肝癌细胞淋巴细胞介导细胞毒性的阻断作用。
Nat New Biol. 1972 Aug 9;238(84):185-6. doi: 10.1038/newbio238185a0.
8
Immunological reactions involving two cell types.涉及两种细胞类型的免疫反应。
Prog Allergy. 1969;13:174-272.
9
Mechanisms of immunologic enhancement.免疫增强机制。
Transplant Proc. 1970 Mar;2(1):68-75.