Mertz J E, Spence K D
J Bacteriol. 1972 Sep;111(3):778-83. doi: 10.1128/jb.111.3.778-783.1972.
The methionine adenosyltransferase is repressed in Saccharomyces cerevisiae during growth in the presence of excess methionine. The relationship of this repression to the level of intracellular S-adenosylmethionine is discussed. In conjunction with these studies, an ethionine-resistant mutant has been investigated which has a low level of methionine adenosyltransferase under all conditions tested. The mechanism of ethionine resistance in the latter strain apparently depends on its inability to form large quantities of intracellular S-adenosylethionine. With respect to the methionine adenosyltransferase, there is no apparent interaction between ethionine-resistant and ethionine-sensitive alleles when both are present in the heterozygous diploid.
在酿酒酵母中，当存在过量甲硫氨酸时，甲硫氨酸腺苷转移酶会受到抑制。本文讨论了这种抑制作用与细胞内S-腺苷甲硫氨酸水平的关系。结合这些研究，对一个抗乙硫氨酸突变体进行了研究，该突变体在所有测试条件下甲硫氨酸腺苷转移酶水平都很低。后一种菌株中抗乙硫氨酸的机制显然取决于其无法形成大量细胞内S-腺苷乙硫氨酸。就甲硫氨酸腺苷转移酶而言，当抗乙硫氨酸和乙硫氨酸敏感等位基因同时存在于杂合二倍体中时，它们之间没有明显的相互作用。
