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被动抗体对免疫反应的调节。IV. IgG1和IgG2抗半抗原抗体的作用。

Modulation of the immune response by passive antibodies. IV. Effects of IgG1 and IgG2 anti-hapten antibodies.

作者信息

Neveu P J, Micusan V V, Fafard A, Borduas A G

出版信息

Immunology. 1978 Jul;35(1):129-32.

PMID:680796
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1457217/
Abstract

The effects of IgG1 and IgG2 anti-hapten antibodies waere studied on celluar and humoral reactions induced by immunization with a hapten-carrier complex. IgG2 was shown to depress delayed hypersensitivity reactions to the carrier and to enhance anaphylactic reactions to both the hapten and the carrier whereas IgG1 appeared to have no activity except a little enhancing effect on antibody synthesis to the carrier. The regulatory role of IgG2 antibodies, which were cytophilic for macrophages, in the immune response to a hapten-carrier conjugate is discussed.

摘要

研究了IgG1和IgG2抗半抗原抗体对用半抗原-载体复合物免疫诱导的细胞和体液反应的影响。结果表明，IgG2可抑制对载体的迟发型超敏反应，并增强对半抗原和载体的过敏反应，而IgG1除了对载体抗体合成有轻微增强作用外似乎没有活性。本文讨论了对巨噬细胞具有嗜细胞性的IgG2抗体在对半抗原-载体偶联物免疫反应中的调节作用。

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Immunology. 1982 Mar;45(3):483-92.
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Marked enhancement in vivo of adjuvant activity of muramyl dipeptide to protein antigens and to synthetic weak immunogens with monoclonal anti-muramyl dipeptide antibodies.用单克隆抗胞壁酰二肽抗体在体内显著增强胞壁酰二肽对蛋白质抗原和合成弱免疫原的佐剂活性。
Infect Immun. 1985 Aug;49(2):312-9. doi: 10.1128/iai.49.2.312-319.1985.

本文引用的文献

1
PREPARATION OF PURIFIED ANTI-2,4-DINITROPHENYL ANTIBODIES.纯化抗2,4-二硝基苯基抗体的制备
Methods Med Res. 1964;10:94-102.
2
Cytophilic antibodies in passive aibody induced immune suppression or enhancement.
Nature. 1970 May 9;226(5245):550-1. doi: 10.1038/226550b0.
3
Regulation of the immune response. I. Reduction in ability of specific antibody to inhibit long-lasting IgG immunological priming after removal of the Fc fragment.免疫反应的调节。I. 去除Fc片段后，特异性抗体抑制持久IgG免疫致敏能力的降低。
J Exp Med. 1969 Jun 1;129(6):1183-201. doi: 10.1084/jem.129.6.1183.
4
Macrophage-bound antigens. I. Induction of delayed hypersensitivity and priming for production of serum antibodies in guinea pigs.巨噬细胞结合抗原。I. 豚鼠迟发型超敏反应的诱导及血清抗体产生的致敏作用。
J Immunol. 1972 Aug;109(2):244-54.
5
The mechanism of a hapten-specific helper effect in mice.小鼠中半抗原特异性辅助效应的机制。
J Immunol. 1973 Oct;111(4):1250-6.
6
Regulation of the immune response. VII. In vitro immunosuppression by F(ab') 2 or intact IgG antibodies.免疫反应的调节。VII. F(ab')2 或完整 IgG 抗体的体外免疫抑制作用。
Immunology. 1973 Apr;24(4):735-50.
7
Immunodeviation by passive antibody, an expression of selective immunodepression. I. Action of guinea pig IgG 1 and IgG 2 anti-hapten antibodies.被动抗体导致的免疫偏离，一种选择性免疫抑制的表现。I. 豚鼠IgG 1和IgG 2抗半抗原抗体的作用。
Eur J Immunol. 1973 Feb;3(2):90-5. doi: 10.1002/eji.1830030207.
8
Properties of antibodies cytophilic for macrophages.对巨噬细胞具有亲嗜性的抗体的特性。
J Exp Med. 1966 Jan 1;123(1):119-44. doi: 10.1084/jem.123.1.119.
9
Antigenic specificities of antibodies suppressing induction of delayed hypersensitivity in mice to dinitrophenylated proteins.抑制小鼠对二硝基苯基化蛋白质迟发型超敏反应诱导的抗体的抗原特异性。
Immunology. 1973 Oct;25(4):541-55.
10
Suppression or augmentation of the antihapten response in mice by antibodies of different specificities.不同特异性抗体对小鼠抗半抗原反应的抑制或增强作用。
J Exp Med. 1973 Jul 1;138(1):103-16. doi: 10.1084/jem.138.1.103.

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