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鼠伤寒沙门氏菌感染的免疫：通过聚丙烯酰胺凝胶电泳对主动保护中的抗原进行表征。

Immunity to Salmonella typhimurium infection: characterization of antigens in active protection by polyacrylamide gel electrophoresis.

作者信息

Houchens D P, Wright G L

出版信息

Infect Immun. 1973 Mar;7(3):507-11. doi: 10.1128/iai.7.3.507-511.1973.

DOI:10.1128/iai.7.3.507-511.1973
PMID:4576683
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC422711/
Abstract

Immunity to challenge with Salmonella typhimurium (strain SR-11) was studied in NIH/NMRI Swiss mice. Viable organisms induced the best protection, but ribosomes were the best immunogen of the subcellular fractions. Antigens with lower concentrations of protein did not induce protection as well as antigens which had higher concentrations of protein. Acrylamide gel electrophoresis of the SR-11 subcellular components, fractionation, and differential staining of the gel columns indicated that the immunogen is a high-molecular-weight glycoprotein or mucopolysaccharide.

摘要

在NIH/NMRI瑞士小鼠中研究了对鼠伤寒沙门氏菌（菌株SR-11）攻击的免疫力。活的生物体诱导出最佳保护作用，但核糖体是亚细胞组分中最佳的免疫原。蛋白质浓度较低的抗原诱导的保护作用不如蛋白质浓度较高的抗原。对SR-11亚细胞组分进行丙烯酰胺凝胶电泳、凝胶柱分级分离和差异染色表明，免疫原是一种高分子量糖蛋白或粘多糖。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdd4/422711/ef0042481729/iai00255-0196-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdd4/422711/90ab30253dae/iai00255-0195-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdd4/422711/ef0042481729/iai00255-0196-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdd4/422711/90ab30253dae/iai00255-0195-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdd4/422711/ef0042481729/iai00255-0196-a.jpg

相似文献

1
Immunity to Salmonella typhimurium infection: characterization of antigens in active protection by polyacrylamide gel electrophoresis.鼠伤寒沙门氏菌感染的免疫：通过聚丙烯酰胺凝胶电泳对主动保护中的抗原进行表征。
Infect Immun. 1973 Mar;7(3):507-11. doi: 10.1128/iai.7.3.507-511.1973.
2
Ribonucleic acid-protein fractions of virulent Salmonella typhimurium as protective immunogens.强毒鼠伤寒沙门氏菌的核糖核酸 - 蛋白质组分作为保护性免疫原
Infect Immun. 1972 Sep;6(3):377-83. doi: 10.1128/iai.6.3.377-383.1972.
3
Immunogenic dialyzable factor derived from a ribosomal fraction of Salmonella typhimurium III. Analysis of resistance induced by dialyzable factors.源自鼠伤寒沙门氏菌核糖体组分的免疫原性可透析因子。III. 可透析因子诱导抗性的分析。
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4
Analysis of immunity to infection with Salmonella typhimurium in outbred mice. II. Isolation and immunogenicity of the protective non-O antigenic component from ribosomal vaccine.远交群小鼠对鼠伤寒沙门氏菌感染的免疫分析。II. 核糖体疫苗中保护性非O抗原成分的分离及其免疫原性
Immunology. 1987 Oct;62(2):235-40.
5
Ribosomal vaccines. I. Immunogenicity of ribosomal fractions isolated from Salmonella typhimurium and Yersinia pestis.核糖体疫苗。I. 从鼠伤寒沙门氏菌和鼠疫耶尔森氏菌中分离出的核糖体组分的免疫原性。
Infect Immun. 1972 Jun;5(6):947-52. doi: 10.1128/iai.5.6.947-952.1972.
6
Identification of protective cell surface proteins in ribosomal fractions from Salmonella typhimurium.鼠伤寒沙门氏菌核糖体组分中保护性细胞表面蛋白的鉴定
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Artificial Salmonella vaccines: O-antigenic oligosaccharide-protein conjugates induce protection against infection with Salmonella typhimurium.人工合成沙门氏菌疫苗：O抗原寡糖-蛋白质偶联物可诱导对鼠伤寒沙门氏菌感染的保护作用。
Infect Immun. 1979 Sep;25(3):863-72. doi: 10.1128/iai.25.3.863-872.1979.
8
Proteins from Salmonella R-mutants mediating protection against Salmonella typhimurium infection in mice. III. Separation and purification of soluble proteins and their use as vaccines and as precipitating antigens.介导小鼠抗鼠伤寒沙门氏菌感染保护作用的鼠伤寒沙门氏菌R突变体蛋白。III. 可溶性蛋白的分离与纯化及其作为疫苗和沉淀抗原的应用。
Zentralbl Bakteriol Mikrobiol Hyg A. 1985 Dec;260(4):448-58. doi: 10.1016/s0176-6724(85)80066-3.
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Localization of the protective antigen in Salmonella typhimurium.鼠伤寒沙门氏菌中保护性抗原的定位
Microbios. 1976;16(64):81-90.
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Isolation and immunological characterization of a 55-kilodalton surface protein from Salmonella typhimurium.鼠伤寒沙门氏菌55千道尔顿表面蛋白的分离及免疫学特性分析
Infect Immun. 1989 May;57(5):1399-404. doi: 10.1128/iai.57.5.1399-1404.1989.

引用本文的文献

1
Vaccines and cell-mediated immunity.疫苗与细胞介导免疫
Bacteriol Rev. 1974 Dec;38(4):371-402. doi: 10.1128/br.38.4.371-402.1974.
2
Variability of protection in inbred mice induced by a ribosomal vaccine prepared from Salmonella typhimurium.由鼠伤寒沙门氏菌制备的核糖体疫苗诱导的近交系小鼠保护作用的变异性。
Infect Immun. 1976 Sep;14(3):652-9. doi: 10.1128/iai.14.3.652-659.1976.
3
Evidence for an extrinsic immunogen in effective ribosomal vaccines from Salmonella typhimurium.来自鼠伤寒沙门氏菌的有效核糖体疫苗中存在外在免疫原的证据。

本文引用的文献

1
Protection against pneumococcal infection by a ribosomal preparation.通过核糖体制剂预防肺炎球菌感染。
Infect Immun. 1971 Jan;3(1):16-23. doi: 10.1128/iai.3.1.16-23.1971.
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Failure of synthetic polynucleotides to affect the immunogenicity of mycobacterial ribonucleic Acid and ribosomal protein preparations.合成多核苷酸不能影响分枝杆菌核糖核酸和核糖体蛋白制剂的免疫原性。
Infect Immun. 1971 Jan;3(1):149-53. doi: 10.1128/iai.3.1.149-153.1971.
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Immunogenic mycobacterial ribosomal and ribonucleic Acid preparations: chemical and physical characteristics.
Infect Immun. 1976 Apr;13(4):1184-92. doi: 10.1128/iai.13.4.1184-1192.1976.
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Direct evidence for the presence of lipopolysaccharide components in Pseudomonas ribosomal vaccine.假单胞菌核糖体疫苗中脂多糖成分存在的直接证据。
Infect Immun. 1977 Aug;17(2):471-3. doi: 10.1128/iai.17.2.471-473.1977.
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Identification of protective cell surface proteins in ribosomal fractions from Salmonella typhimurium.鼠伤寒沙门氏菌核糖体组分中保护性细胞表面蛋白的鉴定
Infect Immun. 1979 Jun;24(3):808-16. doi: 10.1128/iai.24.3.808-816.1979.
6
Comparative efficacy and toxicity of a ribosomal vaccine, acetone-killed cells, lipopolysaccharide, and a live cell vaccine prepared from Salmonella typhhimurium.鼠伤寒沙门氏菌核糖体疫苗、丙酮灭活菌、脂多糖及活细胞疫苗的疗效与毒性比较
Infect Immun. 1978 Feb;19(2):575-82. doi: 10.1128/iai.19.2.575-582.1978.
7
Role of endotoxin contamination in ribiosomal vaccines prepared from Salmonella typhimurium.内毒素污染在由鼠伤寒沙门氏菌制备的核糖体疫苗中的作用。
Infect Immun. 1977 Jul;17(1):98-104. doi: 10.1128/iai.17.1.98-104.1977.
8
Passive immunization against Pseudomonas with a ribosomal vaccine-induced immune serum and immunoglobulin fractions.用核糖体疫苗诱导的免疫血清和免疫球蛋白组分进行针对铜绿假单胞菌的被动免疫。
Infect Immun. 1979 Feb;23(2):509-21. doi: 10.1128/iai.23.2.509-521.1979.
9
Immunogenic capacity of ribosomes of Salmonella typhi interfered with a flagellin-like material contaminant.伤寒沙门氏菌核糖体的免疫原性能力受到一种鞭毛蛋白样物质污染物的干扰。
Infect Immun. 1978 Apr;20(1):161-6. doi: 10.1128/iai.20.1.161-166.1978.
免疫原性分枝杆菌核糖体和核糖核酸制剂：化学和物理特性。
Infect Immun. 1970 Nov;2(5):659-68. doi: 10.1128/iai.2.5.659-668.1970.
4
Immunogenicity of Ribonucleic Acid Preparations Obtained from Salmonella typhimurium.从鼠伤寒沙门氏菌中获得的核糖核酸制剂的免疫原性。
Infect Immun. 1970 Jun;1(6):574-82. doi: 10.1128/iai.1.6.574-582.1970.
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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
6
IMMUNOGENIC ACTIVITY OF A RIBOSOMAL FRACTION OBTAINED FROM MYCOBACTERIUM TUBERCULOSIS.从结核分枝杆菌获得的核糖体组分的免疫原活性
J Bacteriol. 1965 May;89(5):1291-8. doi: 10.1128/jb.89.5.1291-1298.1965.
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Studies on the composition of the protein from Escherichia coli ribosomes.大肠杆菌核糖体蛋白质组成的研究。
Proc Natl Acad Sci U S A. 1961 Jan 15;47(1):18-23. doi: 10.1073/pnas.47.1.18.
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Degradation of tobacco mosaic virus with acetic acid.用乙酸降解烟草花叶病毒。
Virology. 1957 Aug;4(1):1-4. doi: 10.1016/0042-6822(57)90038-7.
9
Immunity induced by ribosomal extracts from Staphylococcus aureus.金黄色葡萄球菌核糖体提取物诱导的免疫
J Reticuloendothel Soc. 1970 Jul;8(1):66-73.
10
Antibacterial immunity induced by ribosomal vaccines.核糖体疫苗诱导的抗菌免疫
J Reticuloendothel Soc. 1970 Jul;8(1):13-24.