Casals J, Buckley S M, Barry D W
Appl Microbiol. 1973 May;25(5):755-62. doi: 10.1128/am.25.5.755-762.1973.
Mice vaccinated with a single injection of formalin-inactivated suspensions of mouse brain tissue infected with arboviruses were markedly protected against a challenge injection administered hours later. The protection observed during the first 2 days after vaccination seemed to be nonspecific, in that it appeared not only with the homologous system but also between arboviruses of different antigenic groups; this phase may be associated with an interferon-like activity of the serum. Overlapping the nonspecific phase was one of specific protection, which seemed to be well-established in its own right by day 3 or 4 after vaccination. Serum neutralizing antibodies against the homologous viruses were detected as early as 24 h after vaccination and in almost all instances by day 3.
用感染虫媒病毒的小鼠脑组织福尔马林灭活悬液单次注射接种的小鼠,对数小时后给予的激发注射有显著的保护作用。接种后前2天观察到的保护作用似乎是非特异性的,因为它不仅在同源系统中出现,而且在不同抗原组的虫媒病毒之间也出现;这一阶段可能与血清的干扰素样活性有关。与非特异性阶段重叠的是特异性保护阶段,在接种后第3天或第4天,这种特异性保护似乎已充分确立。接种后24小时即可检测到针对同源病毒的血清中和抗体,几乎在所有情况下,到第3天时都能检测到。