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链球菌的电子显微镜研究。II. A组碳水化合物。

Electron microscopic studies on streptococci. II. Group A carbohydrate.

作者信息

Swanson J, Gotschlich E C

出版信息

J Exp Med. 1973 Jul 1;138(1):245-58. doi: 10.1084/jem.138.1.245.

DOI:10.1084/jem.138.1.245
PMID:4577619
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2180534/
Abstract

The location of Group A carbohydrate in the streptococcal cell wall has been studied by several ultrastructural techniques. The findings, based largely on use of ferritin- and horseradish peroxidase-conjugated antibodies, are interpreted as demonstrating a discrete laminar distribution of the group-specific polysaccharide. This carbohydrate layer is located on the outermost surface of the cell wall in organisms lacking protein cell wall antigens.

摘要

已通过多种超微结构技术研究了A群碳水化合物在链球菌细胞壁中的位置。这些发现主要基于使用铁蛋白和辣根过氧化物酶偶联抗体，被解释为表明该群特异性多糖呈离散的层状分布。在缺乏蛋白质细胞壁抗原的生物体中，这种碳水化合物层位于细胞壁的最外表面。

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本文引用的文献

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DETECTION OF STREPTOCOCCAL GROUP-SPECIFIC ANTIBODIES IN HUMAN SERA.人血清中链球菌群特异性抗体的检测
J Exp Med. 1965 Aug 1;122(2):195-205. doi: 10.1084/jem.122.2.195.
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IMPROVED TECHNIQUE FOR THE PREPARATION OF STREPTOCOCCAL CELL WALLS.制备链球菌细胞壁的改良技术。
J Bacteriol. 1964 Oct;88(4):1198-200. doi: 10.1128/jb.88.4.1198-1200.1964.
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SYMPOSIUM ON RELATIONSHIP OF STRUCTURE OF MICROORGANISMS TO THEIR IMMUNOLOGICAL PROPERTIES. IV. ANTIGENIC AND BIOCHEMICAL COMPOSITION OF HEMOLYTIC STREPTOCOCCAL CELL WALLS.微生物结构与其免疫学性质关系研讨会。IV. 溶血性链球菌细胞壁的抗原和生化组成。
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Variation in the group-specific carbohydrate of group A streptococci. II. Studies on the chemical basis for serological specificity of the carbohydrates.A组链球菌群特异性碳水化合物的变异。II. 碳水化合物血清学特异性的化学基础研究。
J Exp Med. 1956 Nov 1;104(5):629-43. doi: 10.1084/jem.104.5.629.
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The ultrastructural basis of capillary permeability studied with peroxidase as a tracer.以过氧化物酶为示踪剂研究毛细血管通透性的超微结构基础。
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Coupling of enzymes to proteins with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies.用戊二醛将酶与蛋白质偶联。偶联物用于抗原和抗体的检测。
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Electron microscopic studies on opaque colony variants of group A streptococci.A组链球菌不透明菌落变体的电子显微镜研究。
J Bacteriol. 1969 Oct;100(1):505-11. doi: 10.1128/jb.100.1.505-511.1969.
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Degradation of group A streptococcal cell walls by egg-white lysozyme and human lysosomal enzymes.蛋清溶菌酶和人溶酶体酶对A组链球菌细胞壁的降解作用。
Infect Immun. 1972 Sep;6(3):403-13. doi: 10.1128/iai.6.3.403-413.1972.