更年期潮热：一种非激素药物的双盲试验
Menopausal flushing: double-blind trial of a non-hormonal medication.
作者信息
Clayden J R, Bell J W, Pollard P
出版信息
Br Med J. 1974 Mar 9;1(5905):409-12. doi: 10.1136/bmj.1.5905.409.
Abstract
A multicentre, placebo-controlled, double-blind, cross-over study conducted in general practice on 100 patients has shown clonidine to have a statistically highly significant effect in controlling the number and the severity and duration of menopausal flushes. The relatively mild side effects and the absence of potentially harmful oestrogenic effects suggest that clonidine in the dose range 25 to 75 mug twice daily is a useful addition or alternative to the existing therapy for this common symptom of the menopause.
摘要
在普通医疗实践中对100名患者进行的一项多中心、安慰剂对照、双盲、交叉研究表明，可乐定在控制更年期潮热的次数、严重程度和持续时间方面具有统计学上的高度显著效果。相对较轻的副作用以及不存在潜在有害的雌激素效应表明，每日两次服用剂量在25至75微克范围内的可乐定，对于更年期这一常见症状的现有治疗方法而言，是一种有益的补充或替代方案。
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