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赭曲霉毒素A引起的免疫抑制及其由苯丙氨酸的预防作用

Immunosuppression by ochratoxin A and its prevention by phenylalanine.

作者信息

Haubeck H D, Lorkowski G, Kölsch E, Röschenthaler R

出版信息

Appl Environ Microbiol. 1981 Apr;41(4):1040-2. doi: 10.1128/aem.41.4.1040-1042.1981.

DOI:10.1128/aem.41.4.1040-1042.1981
PMID:7235701
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC243853/
Abstract

Ochratoxin A, a toxin of Aspergillus ochraceus, suppresses the immune response to sheep erythrocytes in BALB/c mice at doses as low as 0.005 microgram/kg of body weight. This effect is prevented by phenylalanine.

摘要

赭曲霉毒素A，一种由赭曲霉产生的毒素，在剂量低至0.005微克/千克体重时就能抑制BALB/c小鼠对绵羊红细胞的免疫反应。苯丙氨酸可预防这种效应。

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Immunosuppression by ochratoxin A and its prevention by phenylalanine.赭曲霉毒素A引起的免疫抑制及其由苯丙氨酸的预防作用
Appl Environ Microbiol. 1981 Apr;41(4):1040-2. doi: 10.1128/aem.41.4.1040-1042.1981.
2
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Phenylalanine prevents acute poisoning by ochratoxina in mice.
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本文引用的文献

1
Ochratoxin A in blood from slaughter pigs in Sweden: use in evaluation of toxin content of consumed feed.瑞典屠宰猪血液中的赭曲霉毒素A：用于评估所消费饲料的毒素含量
Appl Environ Microbiol. 1980 Apr;39(4):828-30. doi: 10.1128/aem.39.4.828-830.1980.
2
Interaction of ochratoxin A with bovine serum albumin.
Arch Biochem Biophys. 1971 Dec;147(2):359-66. doi: 10.1016/0003-9861(71)90391-2.
3
In vivo and in vitro inhibition of protein synthesis in Bacillus stearothermophilus by ochratoxin A.
Biochem Biophys Res Commun. 1978 Jul 28;83(2):398-405. doi: 10.1016/0006-291x(78)91004-5.
4
Ochratoxin A in pig blood: method of analysis and use as a tool for feed studies.猪血中的赭曲霉毒素A：分析方法及作为饲料研究工具的用途
Appl Environ Microbiol. 1979 Nov;38(5):772-6. doi: 10.1128/aem.38.5.772-776.1979.
5
Action of ochratoxin A on cultured hepatoma cells--reversion of inhibition by phenylalanine.
FEBS Lett. 1979 Aug 15;104(2):287-90. doi: 10.1016/0014-5793(79)80834-0.
6
Inhibition of phenylalanine tRNA synthetase from Bacillus subtilis by ochratoxin A.
FEBS Lett. 1977 Nov 15;83(2):341-7. doi: 10.1016/0014-5793(77)81037-5.
7
In vitro inhibition of yeast phenylalanyl-tRNA synthetase by ochratoxin A.
Chem Biol Interact. 1979 Feb;24(2):257-61. doi: 10.1016/0009-2797(79)90013-9.
8
[Preventive action of phenylalanine on acute intoxication of ochratoxin-A].
C R Seances Acad Sci D. 1979 Nov 19;289(13):915-8.
9
Effect of ochratoxin and aflatoxin on serum proteins, complement activity, and antibody production to Brucella abortus in guinea pigs.赭曲霉毒素和黄曲霉毒素对豚鼠血清蛋白、补体活性及抗布鲁氏菌抗体产生的影响。
Appl Microbiol. 1975 Jan;29(1):27-9. doi: 10.1128/am.29.1.27-29.1975.
10
Induction of autolysis in Bacillus subtilis by ochratoxin A.赭曲霉毒素A诱导枯草芽孢杆菌自溶
Can J Microbiol. 1978 May;24(5):563-8. doi: 10.1139/m78-091.