Bergstein J M, Hoyer J R, Michael A F
Am J Pathol. 1974 Apr;75(1):195-202.
The effect of endotoxin on glomerular fibrinolysis in pregnant and nonpregnant rats was studied using a fibrin slide technic. Glomerular fibrinolytic activity was present and light microscopy was normal following endotoxin or saline injection in nonpregnant rats. In pregnant rats, fibrin was regularly detected within glomerular capillaries 2 hours following administration of endotoxin but was completely removed within 48 hours. Glomerular fibrinolytic activity was present throughout this time interval. These studies suggest that glomerular fibrinolytic activity plays an important role in the removal of glomerular fibrin.
采用纤维蛋白玻片技术研究了内毒素对妊娠和未妊娠大鼠肾小球纤维蛋白溶解的影响。未妊娠大鼠注射内毒素或生理盐水后，肾小球存在纤维蛋白溶解活性，且光镜检查正常。在妊娠大鼠中，注射内毒素2小时后，肾小球毛细血管内可经常检测到纤维蛋白，但在48小时内可完全清除。在整个这段时间内都存在肾小球纤维蛋白溶解活性。这些研究表明，肾小球纤维蛋白溶解活性在肾小球纤维蛋白的清除中起重要作用。
