携带R因子的大肠杆菌对青紫霉素的磷酸化作用
Phosphorylation of lividomycin by Escherichia coli carrying an R factor.
作者信息
Yamaguchi M, Koshi T, Kobayashi F, Mitsuhashi S
出版信息
Antimicrob Agents Chemother. 1972 Sep;2(3):142-6. doi: 10.1128/AAC.2.3.142.
Abstract
A lividomycin-phosphorylating enzyme from a lividomycin-resistant strain of Escherichia coli carrying an R factor was partially purified by fractionation with ammonium sulfate and Sephadex G-100 column chromatography. The enzyme inactivated, in the presence of adenosine triphosphate and Mg(2+), several antibiotics having a d-ribose moiety linked to 2-deoxystreptamine, i.e., lividomycin A and B, neomycin, paromomycin, and vistamycin, but did not inactivate the kanamycins, streptomycin, or the gentamicin C components. Chemical studies of the inactivated product suggested that the phosphorylated site of the inactivated lividomycin was the hydroxyl group of the d-ribose moiety.
摘要
从携带R因子的抗利福霉素大肠杆菌菌株中分离得到一种利福霉素磷酸化酶，通过硫酸铵分级分离和Sephadex G - 100柱层析进行部分纯化。该酶在三磷酸腺苷和Mg(2+)存在的情况下，能使几种具有与2 - 脱氧链霉胺相连的d - 核糖部分的抗生素失活，即利福霉素A和B、新霉素、巴龙霉素和维斯他霉素，但不能使卡那霉素、链霉素或庆大霉素C组分失活。对失活产物的化学研究表明，失活的利福霉素的磷酸化位点是d - 核糖部分的羟基。
相似文献
1
Phosphorylation of lividomycin by Escherichia coli carrying an R factor.携带R因子的大肠杆菌对青紫霉素的磷酸化作用
Antimicrob Agents Chemother. 1972 Sep;2(3):142-6. doi: 10.1128/AAC.2.3.142.
2
Lividomycin resistance in staphylococci by enzymatic phosphorylation.葡萄球菌中通过酶促磷酸化产生的青紫霉素耐药性。
Antimicrob Agents Chemother. 1973 Jul;4(1):1-5. doi: 10.1128/AAC.4.1.1.
3
[Isolation and substrate specificity of neomycin (paromomycin)--phosphotransferase from Actinomyces fradiae, a producer of neomycin].
Antibiotiki. 1977 Dec;22(12):1066-70.
4
[Phosphate group donors for neomycin inactivation by resistant microorganism strains].
Antibiotiki. 1978 Mar;23(3):235-8.
5
Phosphorylation of kanamycin, lividomycin A, amd butirosin B by Providencia stuartii.斯氏普罗威登斯菌对卡那霉素、青紫霉素A和丁胺卡那霉素B的磷酸化作用
Antimicrob Agents Chemother. 1974 Dec;6(6):821-4. doi: 10.1128/AAC.6.6.821.
6
Antibacterial activity of lividomycin toward R factor-resistant strains of Escherichia coli.青紫霉素对大肠杆菌R因子抗性菌株的抗菌活性。
Antimicrob Agents Chemother. 1972 Feb;1(2):139-42. doi: 10.1128/AAC.1.2.139.
7
Mechanism of resistance to aminoglycoside antibiotics in nebramycin-producing Streptomyces tenebrarius.产生暗霉素的黑暗链霉菌对氨基糖苷类抗生素的耐药机制。
J Antibiot (Tokyo). 1982 Aug;35(8):1020-5. doi: 10.7164/antibiotics.35.1020.
8
Phosphorylation and inactivation of aminoglycosidic antibiotics by E. coli carrying R factor.携带R因子的大肠杆菌对氨基糖苷类抗生素的磷酸化及失活作用
J Antibiot (Tokyo). 1968 Jan;21(1):13-21. doi: 10.7164/antibiotics.21.13.
9
Two enzymes which phosphorylate neomycin and kanamycin in Escherichia coli strains carrying R factors.在携带R因子的大肠杆菌菌株中使新霉素和卡那霉素磷酸化的两种酶。
Antimicrob Agents Chemother. 1973 Feb;3(2):266-9. doi: 10.1128/AAC.3.2.266.
10
[Aminoglycoside-3'-phosphotransferase I from aminoglycoside-polyresistant strain E. coli 182].[来自氨基糖苷多抗性菌株大肠杆菌182的氨基糖苷-3'-磷酸转移酶I]
Biokhimiia. 1978 Dec;43(12):2154-62.
引用本文的文献
1
Phosphorylation of kanamycin, lividomycin A, amd butirosin B by Providencia stuartii.斯氏普罗威登斯菌对卡那霉素、青紫霉素A和丁胺卡那霉素B的磷酸化作用
Antimicrob Agents Chemother. 1974 Dec;6(6):821-4. doi: 10.1128/AAC.6.6.821.
2
Lividomycin resistance in staphylococci by enzymatic phosphorylation.葡萄球菌中通过酶促磷酸化产生的青紫霉素耐药性。
Antimicrob Agents Chemother. 1973 Jul;4(1):1-5. doi: 10.1128/AAC.4.1.1.
3
Selective phosphorylation of the 5''-hydroxy group of ribostamycin by a new enzyme from Pseudomonas aeruginosa.铜绿假单胞菌中一种新酶对核糖霉素5'-羟基的选择性磷酸化作用。
Antimicrob Agents Chemother. 1974 Jan;5(1):92-4. doi: 10.1128/AAC.5.1.92.
4
Drug resistance plasmids.耐药质粒
Mol Cell Biochem. 1979 Aug 15;26(3):135-81. doi: 10.1007/BF00423044.
本文引用的文献
1
Recent developments in the chemistry of gentamicin.庆大霉素化学的最新进展。
J Infect Dis. 1969 Apr-May;119(4):342. doi: 10.1093/infdis/119.4-5.342.
2
Inactivation and phosphorylation of kanamycin by drug-resistant Staphylococcus aureus.耐药金黄色葡萄球菌对卡那霉素的灭活与磷酸化作用
Appl Microbiol. 1968 Sep;16(9):1282-4. doi: 10.1128/am.16.9.1282-1284.1968.
3
Studies on antibiotic SF-733. A new antibiotic. II. Chemical structure of antibiotic SF-733.抗生素SF-733的研究。一种新型抗生素。II. 抗生素SF-733的化学结构。
J Antibiot (Tokyo). 1970 Apr;23(4):173-83. doi: 10.7164/antibiotics.23.173.
4
Studies on new antibiotic lividomycins. IV. Structure of lividomycin A.新型抗生素青紫霉素的研究。IV. 青紫霉素A的结构
J Antibiot (Tokyo). 1971 Aug;24(8):511-8. doi: 10.7164/antibiotics.24.511.
5
Studies on new antibiotic lividomycins. 3. Partial structure of lividomycin A.新型抗生素青紫霉素的研究。3. 青紫霉素A的部分结构
J Antibiot (Tokyo). 1971 Aug;24(8):503-10. doi: 10.7164/antibiotics.24.503.
6
Chemical conversion of lividomycin A into lividomycin B.青紫霉素A向青紫霉素B的化学转化。
J Antibiot (Tokyo). 1972 Feb;25(2):149-50. doi: 10.7164/antibiotics.25.149.
7
Enzymatic inactivation of gentamicin C components by cell-free extract from Klebsiella pneumoniae.
J Antibiot (Tokyo). 1971 Oct;24(10):719-21. doi: 10.7164/antibiotics.24.719.
8
3',4'-dideoxy-kanamycin B active against kanamycin-resistant Escherichia coli and Pseudomonas aeruginosa.对卡那霉素耐药的大肠杆菌和铜绿假单胞菌有活性的3',4'-双脱氧卡那霉素B
J Antibiot (Tokyo). 1971 Jul;24(7):485-7. doi: 10.7164/antibiotics.24.485.
9
Enzymatic inactivation of gentamicin C components by cell-free extract from Pseudomonas aeruginosa.铜绿假单胞菌无细胞提取物对庆大霉素C组分的酶促失活作用。
J Antibiot (Tokyo). 1971 Jun;24(6):400-1. doi: 10.7164/antibiotics.24.400.
10
Inactivation of kanamycin, neomycin, and streptomycin by enzymes obtained in cells of Pseudomonas aeruginoa.铜绿假单胞菌细胞中获得的酶对卡那霉素、新霉素和链霉素的灭活作用。
Appl Microbiol. 1968 Sep;16(9):1276-81. doi: 10.1128/am.16.9.1276-1281.1968.
Zotero 插件