Brzezinska M, Davies J
Antimicrob Agents Chemother. 1973 Feb;3(2):266-9. doi: 10.1128/AAC.3.2.266.
Two enzymes which phosphorylate neomycin and kanamycin have been detected in Escherichia coli strains carrying R factors. Neomycin-kanamycin phosphotransferase I can phosphorylate neomycin and kanamycin, but not butirosin. Neomycin-kanamycin phosphotransferase II can phosphorylate all three antibiotics. The enzymes also differ in their response to certain inhibitors of phosphorylation. Neomycin-kanamycin phosphotransferase II is found in certain strains of Pseudomonas aeruginosa.
在携带R因子的大肠杆菌菌株中检测到了两种使新霉素和卡那霉素磷酸化的酶。新霉素-卡那霉素磷酸转移酶I可使新霉素和卡那霉素磷酸化，但不能使丁胺卡那霉素磷酸化。新霉素-卡那霉素磷酸转移酶II可使这三种抗生素都磷酸化。这两种酶对某些磷酸化抑制剂的反应也有所不同。在某些铜绿假单胞菌菌株中发现了新霉素-卡那霉素磷酸转移酶II。
