在携带R因子的大肠杆菌菌株中使新霉素和卡那霉素磷酸化的两种酶。
Two enzymes which phosphorylate neomycin and kanamycin in Escherichia coli strains carrying R factors.
作者信息
Brzezinska M, Davies J
出版信息
Antimicrob Agents Chemother. 1973 Feb;3(2):266-9. doi: 10.1128/AAC.3.2.266.
Abstract
Two enzymes which phosphorylate neomycin and kanamycin have been detected in Escherichia coli strains carrying R factors. Neomycin-kanamycin phosphotransferase I can phosphorylate neomycin and kanamycin, but not butirosin. Neomycin-kanamycin phosphotransferase II can phosphorylate all three antibiotics. The enzymes also differ in their response to certain inhibitors of phosphorylation. Neomycin-kanamycin phosphotransferase II is found in certain strains of Pseudomonas aeruginosa.
摘要
在携带R因子的大肠杆菌菌株中检测到了两种使新霉素和卡那霉素磷酸化的酶。新霉素-卡那霉素磷酸转移酶I可使新霉素和卡那霉素磷酸化，但不能使丁胺卡那霉素磷酸化。新霉素-卡那霉素磷酸转移酶II可使这三种抗生素都磷酸化。这两种酶对某些磷酸化抑制剂的反应也有所不同。在某些铜绿假单胞菌菌株中发现了新霉素-卡那霉素磷酸转移酶II。
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R-factor mediated gentamicin resistance: A new enzyme which modifies aminoglycoside antibiotics.R 因子介导的庆大霉素耐药性：一种修饰氨基糖苷类抗生素的新酶。
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The problems of drug-resistant pathogenic bacteria. R factors: biochemical mechanisms of resistance to aminoglycoside antibiotics.耐药病原菌的问题。R 因子：对氨基糖苷类抗生素耐药的生化机制。
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Aminoglycoside antibiotics: inactivation by phosphorylation in Escherichia coli carrying R factors.氨基糖苷类抗生素：在携带R因子的大肠杆菌中通过磷酸化作用而失活
J Bacteriol. 1969 Nov;100(2):1144-6. doi: 10.1128/jb.100.2.1144-1146.1969.
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Butirosin, a new aminoglycosidic antibiotic complex: isolation and characterization.布替罗星，一种新型氨基糖苷类抗生素复合物：分离与特性鉴定。
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